Molecules 2000, 5(7), 927-936; doi:10.3390/50700927
Article

Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids

1 Institute of Chemistry, Faculty of Natural Sciences & Mathematics, Sts. Cyril and Methodius University, PO Box 162, 1000 Skopje, Macedonia 2 Faculty of Pharmacy, Sts. Cyril and Methodius University, 1000 Skopje, Macedonia 3 Rudjer Boskovic Institute, Bijenicka 54, HR-10001, Zagreb, Croatia
* Author to whom correspondence should be addressed.
Received: 27 March 2000; in revised form: 22 June 2000 / Accepted: 29 June 2000 / Published: 7 July 2000
PDF Full-text Download PDF Full-Text [42 KB, uploaded 7 October 2008 15:39 CEST]
Abstract: Thiols and amines were benzamidomethylated in water solution at room temperature with (benzamidomethyl)triethylammonium chloride (1) in the presence of a small quantity of triethylamine (pH>9). Benzamidomethyl thioethers (3a-d) and (benzamidomethyl) amines or di(benzamidomethyl)amines (5) were obtained in high yields (>90%) as well as S(CH2NHBz)2 in a reaction of 1 with Na2S. Benzamidomethyl esters RCOOCH2NHBz were obtained (60-75%) in reactions of carboxylic acids with 1 in chloroform or dioxane.
Keywords: Benzamidomethylation; thiols; carboxylic acids; amines

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Popovski, E.; Klisarova, L.; Vikic-Topic, D. Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids. Molecules 2000, 5, 927-936.

AMA Style

Popovski E, Klisarova L, Vikic-Topic D. Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids. Molecules. 2000; 5(7):927-936.

Chicago/Turabian Style

Popovski, Emil; Klisarova, Ljiljana; Vikic-Topic, Drazen. 2000. "Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids." Molecules 5, no. 7: 927-936.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert