Molecules 2000, 5(6), 908-915; doi:10.3390/50600908
Article

Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide

Gil Valdo José Da Silva* email, Vladimir Constantino Gomes Heleno and Mauricio Gomes Constantino
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, 14040-901 – Ribeirão Preto – SP, Brazil
* Author to whom correspondence should be addressed.
Received: 18 February 2000 / Accepted: 20 June 2000 / Published: 27 June 2000
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Abstract: Goyazensolide, a biologically active natural product classified as a furoheliangolide, was transformed in a phthalimide derivative that showed an enhanced biological activity against Tripanosoma cruzi. The complex natural product was also reduced with high stereoselectivity by hydrogen/Wilkinson’s catalyst; an epimer of this product was obtained in the reduction with hydrogen/Pd-C.
Keywords: Furo-heliangolides; Goyazensolide; Reduction; Phthalimide derivative; Wilkinson’s catalyst

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Cite This Article

MDPI and ACS Style

Da Silva, G.V.J.; Heleno, V.C.G.; Constantino, M.G. Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide. Molecules 2000, 5, 908-915.

AMA Style

Da Silva GVJ, Heleno VCG, Constantino MG. Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide. Molecules. 2000; 5(6):908-915.

Chicago/Turabian Style

Da Silva, Gil V.J.; Heleno, Vladimir C.G.; Constantino, Mauricio G. 2000. "Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide." Molecules 5, no. 6: 908-915.

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