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Molecules 2000, 5(3), 401-402; doi:10.3390/50300401

Reaction of 2,4-Dinitrochlorobenzene with Aromatic Amines in Toluene: Effect of Nucleophile Structure

1,* , 1, 1, 1 and 2,*
1 Dpto. de Química, Facultad de Ingeniería, Universidad Nacional del Comahue. Buenos Aires 1400. (8300) Neuquén, Argentina 2 Dpto. de Química Orgánica. Facultad de Ciencias Exactas y Naturales. Pabellón II, 3°p, Ciudad Universitaria. U.B.A., Argentina
* Authors to whom correspondence should be addressed.
Published: 22 March 2000
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The kinetics of the reaction of 2,4-dinitrochlorobenzene (DNClB) with aniline and substituted anilines such as p-anisidine, p-toluidine and N-methylaniline have been studied in toluene. Except for N-methylaniline the reactions have shown a third order in amine rate dependence which is consistent with aggregates of the amine acting as the nucleophile. On the other hand, the reaction of DNClB with N-methylaniline under the same conditions shows a linear dependence of the second order rate coefficient, kA, vs [amine], which is consistent with the previous mechanism.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Alvaro, C.E.; Savini, M.C.; Nicotra, V.; Yankelevich, J.S.; Nudelman, N.S. Reaction of 2,4-Dinitrochlorobenzene with Aromatic Amines in Toluene: Effect of Nucleophile Structure. Molecules 2000, 5, 401-402.

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