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Molecules 2000, 5(3), 227-239; doi:10.3390/50300227
Article

Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926

,  and
Institute of Chemistry / Organic and Bioorganic Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010 Graz, Austria
* Author to whom correspondence should be addressed.
Received: 9 February 2000 / Accepted: 29 February 2000 / Published: 3 March 2000
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Abstract

A conformationally rigid polyheterocycle (3) which mimics the putative receptorbound conformation of dihydropyridine-type calcium channel modulators is prepared in a seven-step reaction sequence based on a Biginelli-type cyclocondensation reaction.
Keywords: Dihydropyrimidines; Biginelli reaction; isomünchnones; 1; 3-dipolar cycloaddition reactions; AM1 calculations; conformation Dihydropyrimidines; Biginelli reaction; isomünchnones; 1; 3-dipolar cycloaddition reactions; AM1 calculations; conformation
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Jauk, B.; Pernat, T.; Kappe, C.O. Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926. Molecules 2000, 5, 227-239.

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