Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926

doi:10.3390/50300227

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Molecules 2000, 5(3), 227-239; doi:10.3390/50300227

Article

Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926

Birgit Jauk, Tetiana Pernat and C. Oliver Kappe

Institute of Chemistry / Organic and Bioorganic Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010 Graz, Austria

* Author to whom correspondence should be addressed.

Received: 9 February 2000 / Accepted: 29 February 2000 / Published: 3 March 2000

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Abstract: A conformationally rigid polyheterocycle (3) which mimics the putative receptorbound conformation of dihydropyridine-type calcium channel modulators is prepared in a seven-step reaction sequence based on a Biginelli-type cyclocondensation reaction.

Keywords: Dihydropyrimidines; Biginelli reaction; isomünchnones; 1; 3-dipolar cycloaddition reactions; AM1 calculations; conformation

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MDPI and ACS Style

Jauk, B.; Pernat, T.; Kappe, C.O. Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926. Molecules 2000, 5, 227-239.

AMA Style

Jauk B, Pernat T, Kappe CO. Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926. Molecules. 2000; 5(3):227-239.

Chicago/Turabian Style

Jauk, Birgit; Pernat, Tetiana; Kappe, C. O. 2000. "Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926." Molecules 5, no. 3: 227-239.

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