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Molecules 2000, 5(3), 227-239; doi:10.3390/50300227
Article

Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926

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Received: 9 February 2000; Accepted: 29 February 2000 / Published: 3 March 2000
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Abstract: A conformationally rigid polyheterocycle (3) which mimics the putative receptorbound conformation of dihydropyridine-type calcium channel modulators is prepared in a seven-step reaction sequence based on a Biginelli-type cyclocondensation reaction.
Keywords: Dihydropyrimidines; Biginelli reaction; isomünchnones; 1; 3-dipolar cycloaddition reactions; AM1 calculations; conformation Dihydropyrimidines; Biginelli reaction; isomünchnones; 1; 3-dipolar cycloaddition reactions; AM1 calculations; conformation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jauk, B.; Pernat, T.; Kappe, C.O. Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926. Molecules 2000, 5, 227-239.

AMA Style

Jauk B, Pernat T, Kappe CO. Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926. Molecules. 2000; 5(3):227-239.

Chicago/Turabian Style

Jauk, Birgit; Pernat, Tetiana; Kappe, C. O. 2000. "Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926." Molecules 5, no. 3: 227-239.


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