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Molecules 2000, 5(3), 208-218; doi:10.3390/50300208
Article

Synthesis of Some 2, 6-Disubstituted 4-Amidopyridines and -Thioamidopyridines, and Their Antimycobacterial and Photosynthesis-Inhibiting Activity

1,* , 1, 1, 3, 4 and 2
1 Department of Medicinal Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic 2 Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic 3 Institute of Preventive and Clinic Medicine, Bratislava, Slovak Republic 4 Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic
* Author to whom correspondence should be addressed.
Received: 8 March 1999 / Accepted: 28 February 2000 / Published: 3 March 2000
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Abstract

A group of 26 new 2-halogeno-6-alkylsulfanyl- and 2,6-bis-alkylsulfanyl-4-amidopyridines and corresponding thioamidopyridines was synthesised. Some of the amidopyridines and all thioamidopyridines were tested for their antimycobacterial activity against atypical mycobacterial strains. Promising photosynthesis-inhibiting activity was also found for some of the amidopyridines.
Keywords: Thioamidopyridines; antimycobacterial activity; photosynthesis-inhibiting activity Thioamidopyridines; antimycobacterial activity; photosynthesis-inhibiting activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Miletin, M.; Hartl, J.; Dolezal, M.; Odlerova, Z.; Kralova, K.; Machacek, M. Synthesis of Some 2, 6-Disubstituted 4-Amidopyridines and -Thioamidopyridines, and Their Antimycobacterial and Photosynthesis-Inhibiting Activity. Molecules 2000, 5, 208-218.

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