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Molecules 1999, 4(7), 169-179; doi:10.3390/40700169
Review

Polyalkoxy Nitrones as Chiral Building Blocks in Asymmetric Synthesis

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Received: 23 December 1998; in revised form: 20 March 1999 / Accepted: 29 May 1999 / Published: 4 June 1999
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Abstract: Optically active nitrones derived from both aldoses and dialdoses add metallated heterocycles in a stereocontrolled way depending on the nature of the Lewis acid used as a precomplexing agent of the nitrone. Further elaborations of the resulting hydroxylamines lead to the development of new synthetic methodologies for the preparation of polyalkoxy α-amino aldehydes and α-amino acids. These compounds can be used as key advanced intermediates in the synthesis of a wide range of natural products and derivatives including amino sugars, aza sugars, and complex nucleosides.
Keywords: Nitrones; hydroxylamines; carbohydrates; aminoacids; aminoaldehydes Nitrones; hydroxylamines; carbohydrates; aminoacids; aminoaldehydes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Merino, P.; Tejero, T. Polyalkoxy Nitrones as Chiral Building Blocks in Asymmetric Synthesis. Molecules 1999, 4, 169-179.

AMA Style

Merino P, Tejero T. Polyalkoxy Nitrones as Chiral Building Blocks in Asymmetric Synthesis. Molecules. 1999; 4(7):169-179.

Chicago/Turabian Style

Merino, Pedro; Tejero, Tomás. 1999. "Polyalkoxy Nitrones as Chiral Building Blocks in Asymmetric Synthesis." Molecules 4, no. 7: 169-179.


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