Next Article in Journal
Comparison of Free, Esterified, and Insoluble-Bound Phenolics and Their Bioactivities in Three Organs of Lonicera japonica and L. macranthoides
Previous Article in Journal
Consequences of IDH1/2 Mutations in Gliomas and an Assessment of Inhibitors Targeting Mutated IDH Proteins
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Retraction

Retraction: Zhao et al. Protective Effect of Glycyrrhizic Acid on Alcoholic Liver Injury in Rats by Modulating Lipid Metabolism. Molecules 2018, 23(7), 1623

Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Science, Hebei University, Baoding 071002, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2019, 24(5), 969; https://doi.org/10.3390/molecules24050969
Submission received: 21 November 2018 / Accepted: 14 February 2019 / Published: 9 March 2019
As the authors of the title paper [1], it is with great regret that we inform the readership of Molecules that we have asked the journal’s publisher, MDPI, to retract our paper from the scientific literature. Our reason for this action is that in subsequent work we have obtained results inconsistent with the data published therein and therefore wish to retract this article, pending additional experiments to clarify the discrepancies. In particular, in Figure 1C, for weight increase (g) in groups N, M, P, G1−G7 values of 133 ± 34, 125 ± 39, 126 ± 41, 130 ± 47, 132 ± 36, 127 ± 45, 127 ± 43, 130 ± 37, 131 ± 41 and 128 ± 56, respectively, have since been obtained but there was no significant difference between the weight increase in the model group (M) and normal group (N), which was inconsistent with the previous work. Moreover, for serum TC (Figure 3A in [1]) for groups N, M, P, G1−G7 values of 1.55 ± 0.65, 2.1 ± 0.77 **, 1.49 ± 0.54 ##, 1.61 ± 0.63 ##, 1.92 ± 0.82, 2.0 ± 0.71, 1.98 ± 0.88, 1.83 ± 0.84, 1.89 ± 0.66, and 1.95 ± 0.94, respectively (** p < 0.01 vs. normal group, ## p < 0.01 vs. model group), have been obtained, i.e., values that are completely different from the reported work. Finally, for serum LDL (Figure 3D in [1]) values of 0.62 ± 0.34, 0.81 ± 0.32, 0.82 ± 0.48, 0.75 ± 0.37, 0.79 ± 0.47, 0.81 ± 0.57, 0.61 ± 0.37, 0.87 ± 0.31, 0.66 ± 0.23 and 0.58 ± 0.33, respectively, have now been detected, however there was no significant difference between any of the groups, which was not consistent with the previous work. We wish to apologize to MDPI and of course to the wider scientific community for any inconvenience this action may cause.
The new data in our further study that differs from the data in this paper is concluded below.

References

  1. Huo, X.; Yang, S.; Sun, X.; Meng, X.; Zhao, Y. Protective Effect of Glycyrrhizic Acid on Alcoholic Liver Injury in Rats by Modulating Lipid Metabolism. Molecules 2018, 23, 1623. [Google Scholar] [CrossRef] [PubMed]
Figure 1C. The effect of glycyrrhizic acid (GA) on body weight (Figure 1C). N: normal group, M: model group, P: silybin positive group, G1:18α-GA:18β-GA = 10:0, G2:18α-GA:18β-GA = 8:2, G3:18α-GA:18β-GA = 6:4, G4:18α-GA:18β-GA = 5:5, G5:18α-GA:18β-GA = 4:6, G6:18α-GA:18β-GA = 2:8, G7:18α-GA:18β-GA = 0:10. The values were expressed as mean ± SD (n = 8).
Figure 1C. The effect of glycyrrhizic acid (GA) on body weight (Figure 1C). N: normal group, M: model group, P: silybin positive group, G1:18α-GA:18β-GA = 10:0, G2:18α-GA:18β-GA = 8:2, G3:18α-GA:18β-GA = 6:4, G4:18α-GA:18β-GA = 5:5, G5:18α-GA:18β-GA = 4:6, G6:18α-GA:18β-GA = 2:8, G7:18α-GA:18β-GA = 0:10. The values were expressed as mean ± SD (n = 8).
Molecules 24 00969 g001
Figure 3. The effect of glycyrrhizic acid (GA) on lipid profile, including Serum TC (A), and Serum LDL (D). N: normal group, M: model group, P: silybin positive group, G1:18α-GA:18β-GA = 10:0, G2:18α-GA:18β-GA = 8:2, G3:18α-GA:18β-GA = 6:4, G4:18α-GA:18β-GA = 5:5, G5:18α-GA:18β-GA = 4:6, G6:18α-GA:18β-GA = 2:8, G7:18α-GA:18β-GA = 0:10. The values were expressed as mean ± SD (n = 8). ** p < 0.01 vs. normal group, ## p < 0.01 vs. model group.
Figure 3. The effect of glycyrrhizic acid (GA) on lipid profile, including Serum TC (A), and Serum LDL (D). N: normal group, M: model group, P: silybin positive group, G1:18α-GA:18β-GA = 10:0, G2:18α-GA:18β-GA = 8:2, G3:18α-GA:18β-GA = 6:4, G4:18α-GA:18β-GA = 5:5, G5:18α-GA:18β-GA = 4:6, G6:18α-GA:18β-GA = 2:8, G7:18α-GA:18β-GA = 0:10. The values were expressed as mean ± SD (n = 8). ** p < 0.01 vs. normal group, ## p < 0.01 vs. model group.
Molecules 24 00969 g003

Share and Cite

MDPI and ACS Style

Huo, X.; Yang, S.; Sun, X.; Meng, X.; Zhao, Y. Retraction: Zhao et al. Protective Effect of Glycyrrhizic Acid on Alcoholic Liver Injury in Rats by Modulating Lipid Metabolism. Molecules 2018, 23(7), 1623. Molecules 2019, 24, 969. https://doi.org/10.3390/molecules24050969

AMA Style

Huo X, Yang S, Sun X, Meng X, Zhao Y. Retraction: Zhao et al. Protective Effect of Glycyrrhizic Acid on Alcoholic Liver Injury in Rats by Modulating Lipid Metabolism. Molecules 2018, 23(7), 1623. Molecules. 2019; 24(5):969. https://doi.org/10.3390/molecules24050969

Chicago/Turabian Style

Huo, Xiaowei, Sa Yang, Xiaoke Sun, Xiangbo Meng, and Yanyan Zhao. 2019. "Retraction: Zhao et al. Protective Effect of Glycyrrhizic Acid on Alcoholic Liver Injury in Rats by Modulating Lipid Metabolism. Molecules 2018, 23(7), 1623" Molecules 24, no. 5: 969. https://doi.org/10.3390/molecules24050969

Article Metrics

Back to TopTop