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Molecules 2018, 23(9), 2265; https://doi.org/10.3390/molecules23092265

Iodide/H2O2 Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles

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1,2,* , 1
and
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1
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
*
Authors to whom correspondence should be addressed.
Received: 27 July 2018 / Revised: 21 August 2018 / Accepted: 24 August 2018 / Published: 5 September 2018
(This article belongs to the Section Organic Chemistry)
Full-Text   |   PDF [1880 KB, uploaded 5 September 2018]   |  

Abstract

An ammonium iodide/hydrogen peroxide-mediated intramolecular oxidative amination of 3-aminoalkyl-2-oxindoles was achieved, affording the corresponding 3,2′-pyrrolidinyl spirooxindoles and their 6- or 7-membered analogous in moderate to high yields. This metal-free procedure features very mild reaction conditions, non-toxicity and easily handled hydrogen peroxide as a clean oxidant. View Full-Text
Keywords: spirooxindoles; iodine/H2O2; oxidative amination spirooxindoles; iodine/H2O2; oxidative amination
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Gao, Y.-T.; Jin, X.-Y.; Liu, Q.; Liu, A.-D.; Cheng, L.; Wang, D.; Liu, L. Iodide/H2O2 Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2′-Pyrrolidinyl Spirooxindoles. Molecules 2018, 23, 2265.

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