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Molecules 2018, 23(9), 2191; https://doi.org/10.3390/molecules23092191

ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer

1
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia
2
School of Cancer Medicine, La Trobe University, Bundoora, Victoria 3086, Australia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Takaomi Sanda
Received: 15 August 2018 / Revised: 23 August 2018 / Accepted: 23 August 2018 / Published: 30 August 2018
(This article belongs to the Special Issue Transcription Factors as Therapeutic Targets)
Full-Text   |   PDF [37157 KB, uploaded 30 August 2018]   |  

Abstract

The epithelium-specific ETS (ESE) transcription factors (ELF3, ELF5, EHF and SPDEF) are defined by their highly conserved ETS DNA binding domain and predominant epithelial-specific expression profile. ESE transcription factors maintain normal cell homeostasis and differentiation of a number of epithelial tissues, and their genetic alteration and deregulated expression has been linked to the progression of several epithelial cancers. Herein we review the normal function of the ESE transcription factors, the mechanisms by which they are dysregulated in cancers, and the current evidence for their role in cancer progression. Finally, we discuss potential therapeutic strategies for targeting or reactivating these factors as a novel means of cancer treatment. View Full-Text
Keywords: ELF3; ELF5; EHF; SPDEF; transcription factor; cancer ELF3; ELF5; EHF; SPDEF; transcription factor; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Luk, I.Y.; Reehorst, C.M.; Mariadason, J.M. ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer. Molecules 2018, 23, 2191.

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