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Molecules 2018, 23(9), 2114; https://doi.org/10.3390/molecules23092114

Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice

1
UNESP—São Paulo State University/Coastal Campus of São Vicente, Laboratory of Bioprospection of Natural Products (LBPN) Pça Infante Dom Henrique S/N, 11330-900 São Vicente, SP, Brazil
2
Clinical Pharmacology and Gastroenterology Unit, USF—São Francisco University, Av. São Francisco de Assis, 218, 12916-900 Bragança Paulista, SP, Brazil
3
Laboratório de Estudos Avançados em Fitomedicamentos (LEAF), UFMA—Federal University of Maranhão, Av. dos Portugueses, 1966-Bacanga, CEP: 65080-805 São Luís, Maranhão, Brazil
4
Department of Biosciences, Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Vila Mathias, 11015-020 Santos City, SP, Brazil
*
Author to whom correspondence should be addressed.
Received: 12 July 2018 / Revised: 5 August 2018 / Accepted: 11 August 2018 / Published: 22 August 2018
(This article belongs to the Special Issue Natural Bioactives in Anti-Obesity Therapy)
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Abstract

No scientific report proves the action of the phytochemicals from the mangrove tree Rhizophora mangle in the treatment of diabetes. The aim of this work is to evaluate the effects of the acetonic extract of R. mangle barks (AERM) on type 2 diabetes. The main chemical constituents of the extract were analyzed by high-performance liquid chromatography (HPLC) and flow injection analysis electrospray-iontrap mass spectrometry (FIA-ESI-IT-MS/MS). High-fat diet (HFD)-fed mice were used as model of type 2 diabetes associated with obesity. After 4 weeks of AERM 5 or 50 mg/kg/day orally, glucose homeostasis was evaluated by insulin tolerance test (kiTT). Hepatic steatosis, triglycerides and gene expression were also evaluated. AERM consists of catechin, quercetin and chlorogenic acids derivatives. These metabolites have nutritional importance, obese mice treated with AERM (50 mg/kg) presented improvements in insulin resistance resulting in hepatic steatosis reductions associated with a strong inhibition of hepatic mRNA levels of CD36. The beneficial effects of AERM in an obesity model could be associated with its inhibitory α-amylase activity detected in vitro. Rhizophora mangle partially reverses insulin resistance and hepatic steatosis associated with obesity, supporting previous claims in traditional knowledge. View Full-Text
Keywords: polyphenols; type 2 diabetes; non-alcoholic fatty liver disease; CD36; catechins polyphenols; type 2 diabetes; non-alcoholic fatty liver disease; CD36; catechins
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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de Souza Mesquita, L.M.; Caria, C.R.P.; Santos, P.S.; Ruy, C.C.; da Silva Lima, N.; Moreira, D.K.T.; da Rocha, C.Q.; Murador, D.C.; de Rosso, V.V.; Gambero, A.; Vilegas, W. Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice. Molecules 2018, 23, 2114.

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