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Molecules 2018, 23(5), 1198; https://doi.org/10.3390/molecules23051198

Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities

Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China
These authors contributed equally to this work.
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Received: 16 April 2018 / Revised: 7 May 2018 / Accepted: 14 May 2018 / Published: 17 May 2018
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Seven pyrrole alkaloids, three of which are novel (phlebopines A–C (13)), were isolated from the fruiting bodies of the edible mushroom Phlebopus portentosus. Their structures were determined on the basis of spectroscopic data. All the isolated compounds were tested for their neuroprotective properties and acetylcholine esterase (AChE) inhibition activities. Compound 7 displayed remarkable neuroprotective effects against hydrogen peroxide (H2O2)-induced neuronal-cell damage in human neuroblastoma SH-SY5Y cells. View Full-Text
Keywords: Phlebopus portentosus; edible mushroom; pyrrole alkaloids; neuroprotection Phlebopus portentosus; edible mushroom; pyrrole alkaloids; neuroprotection
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Sun, Z.; Hu, M.; Sun, Z.; Zhu, N.; Yang, J.; Ma, G.; Xu, X. Pyrrole Alkaloids from the Edible Mushroom Phlebopus portentosus with Their Bioactive Activities. Molecules 2018, 23, 1198.

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