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Molecules 2018, 23(5), 1159; https://doi.org/10.3390/molecules23051159

First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules

Institut de Chimie Organique et Analytique, Université d’Orléans—Pôle de Chimie, UMR CNRS 7311, Rue de Chartres—BP 6759, 45067 Orléans CEDEX 2, France
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Received: 24 April 2018 / Revised: 4 May 2018 / Accepted: 8 May 2018 / Published: 11 May 2018
(This article belongs to the Special Issue Focusing on Sulfur in Medicinal Chemistry)
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Abstract

We report herein a new metal free synthetic pathway to generate tetracyclic compounds from 3-aminothieno[3,2-b]pyridine-2-carboxylate. To enlarge the molecular diversity, we studied the Suzuki coupling of 9-chloro-6H-pyrido[1,2-a]pyrido[2′,3′:4,5]thieno[3,2-d]pyrimidin-6-one and several boronic acids were easily introduced. View Full-Text
Keywords: metal-free; thienopyrimidinone; tetracyclic compounds metal-free; thienopyrimidinone; tetracyclic compounds
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Aounzou, M.; Campos, J.F.; Loubidi, M.; Berteina-Raboin, S. First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules. Molecules 2018, 23, 1159.

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