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Molecules 2018, 23(5), 1082; https://doi.org/10.3390/molecules23051082

Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa

1
Spectroscopic Research, Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary
2
Department of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary
3
Department of Microbiology, University of Szeged, Közép fasor 52, H-6726 Szeged, Hungary
4
Institute of Clinical Microbiology, University of Szeged, Semmelweis u. 6, H- 6725 Szeged Hungary
5
Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary
*
Authors to whom correspondence should be addressed.
Received: 10 April 2018 / Revised: 27 April 2018 / Accepted: 27 April 2018 / Published: 4 May 2018
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Abstract

Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 14. Two of the compounds are lactones—osmundalactone (1) and 5-hydroxy-hex-2-en-4-olide (2)—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B, respectively. The structures of the compounds were established on the basis of NMR and MS spectroscopic analysis. The isolated fungal metabolites were evaluated for their antibacterial activities against several Gram-positive and negative bacteria. In addition, their synergistic effect with cefuroxime against methicillin-resistant Staphylococcus aureus (MRSA) was also evaluated. Compounds 13 proved to possess significant antibacterial activity against multiresistant Acinetobacter baumannii and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. The investigation of the antioxidant effect of the isolated compounds in DPPH and ORAC assays revealed that spiromentins C (3) and B (4) have remarkable antioxidant activity. View Full-Text
Keywords: Tapinella atrotomentosa; terphenyl quinones; antibacterial; antioxidant; multiresistant Acinetobacter baumannii; ESBL Escherichia coli Tapinella atrotomentosa; terphenyl quinones; antibacterial; antioxidant; multiresistant Acinetobacter baumannii; ESBL Escherichia coli
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Béni, Z.; Dékány, M.; Kovács, B.; Csupor-Löffler, B.; Zomborszki, Z.P.; Kerekes, E.; Szekeres, A.; Urbán, E.; Hohmann, J.; Ványolós, A. Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa. Molecules 2018, 23, 1082.

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