Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple
AbstractUltra-performance convergence chromatography is an environmentally-friendly analytical method that uses dramatically reduced amounts of organic solvents. In addition, a robust and highly sensitive chiral separation method was developed for the novel chiral acaricide cyflumetofen by using ultra-performance convergence chromatography coupled with tandem mass spectrometry, which shows that stereoisomer recoveries determined for various apple parts ranged from 78.3% to 119.9%, with the relative standard deviations being lower than 14.0%. The half-lives of (−)-cyflumetofen and (+)-cyflumetofen obtained under 5-fold applied dosage equal to 22.13 and 22.23 days, respectively. For 1.5-fold applied dosage, the respective values were determined as 22.42 and 23.64 days, i.e., the degradation of (−)-cyflumetofen was insignificantly favored over that of its enantiomer. Importantly, cyflumetofen was unevenly distributed in apples, with its relative contents in apple peel, peduncle, and pomace equal to 50%, 22%, and 16%, respectively. The proposed method can be used to efficiently separate and quantify chiral pesticide with advantages of a shorter analysis time, greater sensitivity, and better environmental compatibility. Additionally, the consumption of apples with residue of cyflumetofen did not pose a health risk to the population if the cyflumetofen applied under satisfactory agricultural practices after the long-term dietary risk assessment. View Full-Text
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Guo, J.; Li, M.; Liu, Y.; Wang, F.; Kong, Z.; Sun, Y.; Lu, J.; Jin, N.; Huang, Y.; Liu, J.; Francis, F.; Fan, B. Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple. Molecules 2018, 23, 1060.
Guo J, Li M, Liu Y, Wang F, Kong Z, Sun Y, Lu J, Jin N, Huang Y, Liu J, Francis F, Fan B. Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple. Molecules. 2018; 23(5):1060.Chicago/Turabian Style
Guo, Jing; Li, Minmin; Liu, Yongguo; Wang, Fengzhong; Kong, Zhiqiang; Sun, Yufeng; Lu, Jia; Jin, Nuo; Huang, Yatao; Liu, Jiameng; Francis, Frédéric; Fan, Bei. 2018. "Residue and Dietary Risk Assessment of Chiral Cyflumetofen in Apple." Molecules 23, no. 5: 1060.
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