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Molecules 2018, 23(5), 1009; https://doi.org/10.3390/molecules23051009

Effector–Immunity Pairs Provide the T6SS Nanomachine its Offensive and Defensive Capabilities

1,†
,
2,†
and
1,*
1
Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling 712100, China
2
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
These people contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 19 March 2018 / Revised: 13 April 2018 / Accepted: 23 April 2018 / Published: 26 April 2018
(This article belongs to the Special Issue Protein-Protein Interactions)
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Abstract

Type VI protein secretion systems (T6SSs) are specialized transport apparatus which can target both eukaryotic and prokaryotic cells and play key roles in host–pathogen–microbiota interactions. Therefore, T6SSs have attracted much attention as a research topic during the past ten years. In this review, we particularly summarized the T6SS antibacterial function, which involves an interesting offensive and defensive mechanism of the effector–immunity (E–I) pairs. The three main categories of effectors that target the cell wall, membranes, and nucleic acids during bacterial interaction, along with their corresponding immunity proteins are presented. We also discuss structural analyses of several effectors and E–I pairs, which explain the offensive and defensive mechanisms underpinning T6SS function during bacterial competition for niche-space, as well as the bioinformatics, proteomics, and protein–protein interaction (PPI) methods used to identify and characterize T6SS mediated E–I pairs. Additionally, we described PPI methods for verifying E–I pairs. View Full-Text
Keywords: types VI secretion systems (T6SS); effector–immunity pairs (E–I pairs); protein-protein interaction (PPI); interbacterial competition types VI secretion systems (T6SS); effector–immunity pairs (E–I pairs); protein-protein interaction (PPI); interbacterial competition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Yang, X.; Long, M.; Shen, X. Effector–Immunity Pairs Provide the T6SS Nanomachine its Offensive and Defensive Capabilities. Molecules 2018, 23, 1009.

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