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Molecules 2018, 23(4), 796; https://doi.org/10.3390/molecules23040796

On-Demand Bioadhesive Dendrimers with Reduced Cytotoxicity

1
School of Material Science and Engineering, Beijing University of Chemistry Technology, North Third Ring Road 15, Chaoyang District, Beijing 100029, China
2
Escuela de Ingeniería y Ciencias, Tecnologico de Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey 64849, NL, Mexico
3
School of Materials Science and Engineering, Division of Materials Technology, Nanyang Technological University, Singapore 639798, Singapore
*
Authors to whom correspondence should be addressed.
Academic Editor: Ashok Kakkar
Received: 22 March 2018 / Revised: 22 March 2018 / Accepted: 27 March 2018 / Published: 30 March 2018
Full-Text   |   PDF [37282 KB, uploaded 3 May 2018]   |  

Abstract

Tissue adhesives based on polyamidoamine (PAMAM) dendrimer, grafted with UV-sensitive aryldiazirine (PAMAM-g-diazirine) are promising new candidates for light active adhesion on soft tissues. Diazirine carbene precursors form interfacial and intermolecular covalent crosslinks with tissues after UV light activation that requires no premixing or inclusion of free radical initiators. However, primary amines on the PAMAM dendrimer surface present a potential risk due to their cytotoxic and immunological effects. PAMAM-g-diazirine formulations with cationic pendant amines converted into neutral amide groups were evaluated. In vitro toxicity is reduced by an order of magnitude upon amine capping while retaining bioadhesive properties. The in vivo immunological response to PAMAM-g-diazirine formulations was found to be optimal in comparison to standard poly(lactic-co-glycolic acid) (PLGA) thin films. View Full-Text
Keywords: PAMAM; dendrimers; bioadhesive; diazirine PAMAM; dendrimers; bioadhesive; diazirine
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Gao, F.; Djordjevic, I.; Pokholenko, O.; Zhang, H.; Zhang, J.; Steele, T.W.J. On-Demand Bioadhesive Dendrimers with Reduced Cytotoxicity. Molecules 2018, 23, 796.

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