Next Article in Journal
Progress in Targeted Alpha-Particle Therapy. What We Learned about Recoils Release from In Vivo Generators
Previous Article in Journal
Steroidal Saponins from Vernonia amygdalina Del. and Their Biological Activity
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Molecules 2018, 23(3), 580; https://doi.org/10.3390/molecules23030580

Phenolic Compounds from Belamcanda chinensis Seeds

1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
2
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China
3
University of Chinese Academy of Sciences, Beijing 100049, China
4
College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450008, China
*
Authors to whom correspondence should be addressed.
Received: 4 February 2018 / Revised: 20 February 2018 / Accepted: 21 February 2018 / Published: 5 March 2018
(This article belongs to the Section Natural Products Chemistry)
View Full-Text   |   Download PDF [1350 KB, uploaded 5 March 2018]   |  

Abstract

Two new sucrose derivatives, namely, belamcanosides A (1) and B (2), together with five other known compounds (37), were isolated from the seeds of Belamcanda chinensis (L.) DC. Their structures were identified based on spectroscopic data. Especially, the absolute configurations of fructose and glucose residues in 1 and 2 were assigned by acid hydrolysis, followed by derivatization and gas chromatography (GC) analysis. Among the known compounds, (−)-hopeaphenol (3), (+)-syringaresinol (4), and quercetin (5), were isolated from B. chinensis for the first time. In addition, biological evaluation of 1 and 2 against cholesterol synthesis and metabolism at the gene level was carried out. The results showed that compounds 1 and 2 could regulate the expression of cholesterol synthesis and metabolism-associated genes, including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), squalene epoxidase (SQLE), low density lipoprotein receptor (LDLR), and sortilin (SORT1) genes in HepG2 cells. View Full-Text
Keywords: Belamcanda chinensis; belamcanosides A and B; GC analysis; HMGCR; SQLE; LDLR; SORT1 Belamcanda chinensis; belamcanosides A and B; GC analysis; HMGCR; SQLE; LDLR; SORT1
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Song, Y.-Y.; Liu, Y.; Yan, Y.-M.; Lu, X.-F.; Cheng, Y.-X. Phenolic Compounds from Belamcanda chinensis Seeds. Molecules 2018, 23, 580.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top