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Molecules 2018, 23(2), 330; https://doi.org/10.3390/molecules23020330

Non-Covalent Supported of l-Proline on Graphene Oxide/Fe3O4 Nanocomposite: A Novel, Highly Efficient and Superparamagnetically Separable Catalyst for the Synthesis of Bis-Pyrazole Derivatives

1
Department of Gas and Petroleum, Yasouj University, Gachsaran 75918-74831, Iran
2
Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 14536-33143, Iran
3
Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 14536-33143, Iran
4
Department of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, Italy
5
Marine Pharmaceutical Science Research Center, Ahvaz JundiShapur University of Medical sciences, Ahvaz 14536-33143, Iran
*
Author to whom correspondence should be addressed.
Received: 1 December 2017 / Revised: 12 January 2018 / Accepted: 14 January 2018 / Published: 5 February 2018
(This article belongs to the Section Nanochemistry)
View Full-Text   |   Download PDF [17246 KB, uploaded 5 February 2018]   |  

Abstract

A superparamagnetic graphene oxide/Fe3O4/l-proline nano hybrid that was obtained from the non-covalent immobilization of l-proline on graphene oxide/Fe3O4 nanocomposite was used as a new magnetically separable catalyst for the efficient synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives. The prepared heterogeneous catalyst was characterized using FTIR, TGA, DTG, XRD, TEM, SEM, and elemental analysis techniques. Short reaction times (5–15 min), excellent yields (87–98%), and simple experimental procedure with an easy work-up are some of the advantages of the introduced catalyst. View Full-Text
Keywords: l-proline; nanocomposite; graphene oxide; heterogeneous catalyst; magnetically separable catalyst l-proline; nanocomposite; graphene oxide; heterogeneous catalyst; magnetically separable catalyst
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Keshavarz, M.; Zarei Ahmady, A.; Vaccaro, L.; Kardani, M. Non-Covalent Supported of l-Proline on Graphene Oxide/Fe3O4 Nanocomposite: A Novel, Highly Efficient and Superparamagnetically Separable Catalyst for the Synthesis of Bis-Pyrazole Derivatives. Molecules 2018, 23, 330.

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