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Molecules 2018, 23(2), 243; https://doi.org/10.3390/molecules23020243

HPLC-PDA Combined with Chemometrics for Quantitation of Active Components and Quality Assessment of Raw and Processed Fruits of Xanthium strumarium L.

1
Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China
2
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 528458, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 22 December 2017 / Revised: 17 January 2018 / Accepted: 24 January 2018 / Published: 25 January 2018
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Abstract

As a valuable herbal medicine, the fruits of Xanthium strumarium L. (Xanthii Fructus) have been widely used in raw and processed forms to achieve different therapeutic effects in practice. In this study, a comprehensive strategy was proposed for evaluating the active components in 30 batches of raw and processed Xanthii Fructus (RXF and PXF) samples, based on high-performance liquid chromatography coupled with photodiode array detection (HPLC-PDA). Twelve common peaks were detected and eight compounds of caffeoylquinic acids were simultaneously quantified in RXF and PXF. All the analytes were detected with satisfactory linearity (R2 > 0.9991) over wide concentration ranges. Simultaneously, the chemically latent information was revealed by hierarchical cluster analysis (HCA) and principal component analysis (PCA). The results suggest that there were significant differences between RXF and PXF from different regions in terms of the content of eight caffeoylquinic acids. Potential chemical markers for XF were found during processing by chemometrics. View Full-Text
Keywords: Xanthii Fructus; multi-component quantitation; HPLC-PDA; quality assessment; chemometrics Xanthii Fructus; multi-component quantitation; HPLC-PDA; quality assessment; chemometrics
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Jiang, H.; Yang, L.; Xing, X.; Yan, M.; Guo, X.; Yang, B.; Wang, Q.; Kuang, H. HPLC-PDA Combined with Chemometrics for Quantitation of Active Components and Quality Assessment of Raw and Processed Fruits of Xanthium strumarium L.. Molecules 2018, 23, 243.

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