General Procedure for the Synthesis of Thiourea Derivatives of 2-(1H-indol-3-yl)ethanamine
A solution of 2-(1H-indol-3-yl)ethanamine (0.0038 mol, 0.61 g) in anhydrous acetonitrile (25 mL) was treated with an appropriate isothiocyanate (0.0042 mol) and the mixture was refluxed for 8 h. Then solvent was removed on rotary evaporator. The residue was purified by column chromatography (chloroform/methanol; 9.8:0.2 vol.). The compound was crystallized from acetonitrile or another appropriate solvent.
1-(2-(1H-Indol-3-yl)ethyl)-3-phenylthiourea (
1). This compound was synthesized as described previously [
40].
1-(2-(1H-Indol-3-yl)ethyl)-3-(4-methoxyphenyl)thiourea (2). Yield 87%. m.p. 146–148 °C. 1H-NMR (DMSO-d6) δ (ppm): 3.07 (t, 2H, CH2, J = 6.6 Hz); 3.77 (s, 3H, CH3); 3.89 (t, 2H, CH2, J = 6.3 Hz); 6.42 (s, 1H, NH); 6.71 (d, 1H,CHarom., J = 8.7 Hz); 6.83 (d, 2H, CHarom., J = 9.3 Hz); 7.02 (bs, 1H, NH); 7.35–7.41 (m, 3H, CHarom.); 7.55–7.67 (m, 3H, CHarom.); 7.99 (bs, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 24.6 (CH2), 44.6 (CH2), 55.2 (CH3), 111.3 (C), 111.6 (CH), 113.9 (CH, CH), 118.2 (CH), 118.5 (CH), 120.9 (CH), 122.7 (CH), 125.8 (CH), 127.3 (C), 128.6 (C), 131.5 (C), 136.3 (C), 156.5 (CH), 180.4 (C). HRMS (ESI) calc. for C18H19N3OS [M − H]−: 324.4279, found: 324.4298.
1-(2-(1H-Indol-3-yl)ethyl)-3-(4-methylphenyl)thiourea (
3). This compound was synthesized as described previously [
41].
1-(2-(1H-Indol-3-yl)ethyl)-3-(4-chlorophenyl)thiourea (
4). This compound was synthesized as described previously [
39].
1-(2-(1H-Indol-3-yl)ethyl)-3-benzoylthiourea (
5). This compound was synthesized as described previously [
42].
1-(2-(1H-indol-3-yl)ethyl)-3-(3,4-dichlorophenyl)thiourea (6). Yield 81%. m.p. 168–169 °C. 1H-NMR (DMSO-d6) δ (ppm): 2.99 (t, 2H, CH2, J = 7.2 Hz); 3.76 (q, 2H, CH2, J = 5.4 Hz); 6.98 (t, 1H, CHarom., J = 7.8 Hz); 7.08 (t, 1H,CHarom., J = 7.2 Hz); 7.18 (d, 1H, CHarom., J = 2.4 Hz); 7.30–7.36 (m, 2H, CHarom.); 7.52 (d, 1H,CHarom., J = 8.7 Hz); 7.62 (d, 1H, CHarom., J = 7.8 Hz); 7.85 (s, 1H, CHarom.); 7.99 (bs, 1H, NH); 9.72 (s, 1H, NH); 10.84 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 24.3 (CH2), 44.5 (CH2), 111.4 (C), 111.4 (CH), 118.3 (CH), 118.4 (CH), 120.9 (CH), 122.5 (CH), 122.8 (CH), 123.7 (CH), 125.3 (C), 127.2 (C), 130.2 (C), 130.5 (C), 136.3 (C), 139.7 (CH), 180.2 (C). HRMS (ESI) calc. for C17H15 Cl2N3S [M − H]−: 363.2921, found: 363.2943.
1-(2-(1H-Indol-3-yl)ethyl)-3-(3-bromophenyl)thiourea (7). Yield 79%. m.p. 152–154 °C. 1H-NMR (DMSO-d6) δ (ppm): 3.09 (t, 2H, CH2, J = 6.6 Hz); 3.97 (q, 2H, CH2, J = 5.7 Hz); 6.06 (s, 1H, NH); 6.81 (d, 1H, CHarom., J = 7.2 Hz); 7.00 (s, 1H, CHarom.); 7.05 (d, 1H, CHarom., J = 8.1 Hz); 7.08 (d, 1H, CHarom., J = 9.0 Hz); 7.13 (s, 1H, CHarom.); 7.20 (t, 1H, CHarom., J = 7.2 Hz); 7.29 (d, 1H,CHarom., J = 8.1 Hz); 7.36 (d, 1H, CHarom., J = 8.1 Hz); 7.40 (bs, 1H, NH); 7.57–7.60 (d, 1H, CHarom., J = 8.7 Hz); 8.03 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 24.3 (CH2), 44.5 (CH2), 111.4 (C), 111.5 (CH), 118.3 (CH), 118.5 (CH), 121.0 (CH), 121.1 (CH), 121.3 (CH), 122.8 (CH), 124.9 (CH), 126.3 (C), 127.2 (C), 130.4 (C), 136.3 (C), 141.2 (CH), 180.1 (C). HRMS (ESI) calc. for C17H16BrN3S [M − H]−: 373.2980, found: 373.2978.
1-(2-(1H-Indol-3-yl)ethyl)-3-(4-bromophenyl)thiourea (8). Yield 81%. m.p. 156–158 °C. 1H-NMR (DMSO-d6) δ (ppm): 3.09 (t, 2H, CH2, J = 6.6 Hz); 3.95 (t, 2H, CH2, J = 6.6 Hz); 6.24 (bs, 1H, NH); 6.71 (d, 1H, CHarom., J = 8.7 Hz); 6.97 (s, 1H, CHarom.); 7.11 (t, 1H, CHarom., J = 7.8 Hz); 7.17–7.29 (m, 3H, CHarom.); 7.39 (d, 1H,CHarom., J = 8.1 Hz); 7.56 (d, 1H, CHarom., J = 8.1 Hz); 7.62 (bs, 1H, NH); 8.01 (bs, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 24.4 (CH2), 44.5 (CH2), 111.4 (C), 111.5 (CH), 115.8 (CH), 118.2 (CH, CH), 118.5 (CH), 121.0 (CH), 122.8(CH), 124.7 (CH), 127.2 (CH), 131.3(C, C), 136.3 (C), 138.7, 180.1 (C). HRMS (ESI) calc. for C17H16BrN3S [M − H]−: 373.2980, found: 373.2978. Crystal data: crystal system monoclinic, space group Cc, unit cell dimensions a = 35.17(2), b = 10.863(4), c = 8.798(3) Å, β = 100.44(5) °, V = 3306(3) Å3; Z = 8, dc = 1.504 g/cm3, μ = 2.613 mm−1, F(000) = 1520. A crystal of dimensions 0.20 × 0.15 × 0.04 mm was used for intensity measurements. Within the θ range 2.98–26.31° (−43 ≤ h ≤ 33, −13 ≤ k ≤ 13, −7 ≤ l ≤ 10), 9510 reflections were collected. The 4871 unique reflections [R(int) = 0.0699] were used for the refinement of 397 parameters. Final R indices on F2 for 2599 observed reflections [I > 2σ(I)] were: R1 = 0.0615, wR2 = 0.0825, goodness-of-fit = 0.941, Δρmax/min = 0.57/−0.44 e Å−3.
1-(2-(1H-Indol-3-yl)ethyl)-3-cyclohexylthiourea (
9). This compound was synthesized as described previously [
40].
1-(2-(1H-Indol-3-yl)ethyl)-3-benzylthiourea (
10). This compound was synthesized as described previously [
43].
1-(2-(1H-Indol-3-yl)ethyl)-3-(2-fluorophenyl)thiourea (11). Yield 90%. m.p. 167–168 °C. 1H-NMR (DMSO-d6) δ (ppm): 3.09 (t, 2H, CH2, J = 6.6 Hz); 3.98(t, 2H, CH2, J = 6.3 Hz); 6.06 (bs, 1H, NH); 6.88–6.98 (m, 3H, CHarom.); 7.04–7.17 (m, 3H, CHarom.); 7.35 (d, 2H,CHarom., J = 8.1 Hz); 7.58 (d, 1H, CHarom., J = 7.5 Hz); 7.62 (bs, 1H, NH); 7.99 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 24.5 (CH2), 44.7 (CH2), 111.3 (C), 111.5 (CH), 115.6 (CH), 115.9 (d, J = 31.2 Hz, CH), 118.2 (CH), 118.5 (CH), 121.0 (CH), 122.8 (CH), 124.0 (d, J = 3.7 Hz, CH), 126.6 (d, J = 11.8 Hz, CH), 127.2 (C), 127.9 (d, J = 7.8 Hz, C), 136.3 (C), 157.5 (d, J = 245.3Hz, CH), 181.1 (C). HRMS (ESI) calc. for C17H16FN3S [M − H]−: 312.3924, found: 312.3921.
1-(2-(1H-Indol-3-yl)ethyl)-3-(3-fluorophenyl)thiourea (12). Yield 88%. m.p. 162–164 °C. 1H-NMR (DMSO-d6) δ (ppm): 3.10 (t, 2H, CH2, J = 6.6 Hz); 3.98 (q, 2H, CH2, J = 5.7 Hz); 6.13 (s, 1H, NH); 6.65 (d, 2H, CHarom., J = 6.9 Hz); 6.87 (d, 1H, CHarom., J = 6.9 Hz); 6.98 (s, 1H, CHarom.); 7.05–7.23 (m, 3H, CHarom.); 7.37 (d, 2H, CHarom., J = 8.1 Hz); 7.49 (s, 1H, NH); 7.58–7.60 (d, 2H, CHarom., J = 7.8 Hz); 8.01 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 24.4 (CH2), 44.5 (CH2), 109.2 (C), 110.3 (d, J = 24,9 Hz, CH), 111.4 (d, J = 21,3 Hz, CH), 111.5 (CH), 118.3 (CH), 118.5 (q, J = 3.9 Hz, CH), 121.0 (CH), 122.8 (CH), 127.2 (CH), 130.1 (q, J = 32 Hz, CH), 136.3 (C), 141.3 (d, J = 10.8 Hz, C), 160.3 (d, J = 242 Hz, C), 163.5 (CH), 180.1 (C). HRMS (ESI) calc. for C17H16FN3S [M − H]−: 312.3924, found: 312.3921.
1-(2-(1H-Indol-3-yl)ethyl)-3-(2-chlorophenyl)thiourea (13). Yield 79%. m.p. 170–172 °C. 1H-NMR (DMSO-d6) δ (ppm): 2.97 (t, 2H, CH2, J = 7.5 Hz); 3.75 (q, 2H, CH2, J = 5.7 Hz); 6.98 (t, 1H,CHarom., J = 7.5 Hz); 7.07 (t, 1H, CHarom., J = 6.9 Hz); 7.16–7.35 (m, 4H, CHarom.); 7.47 (d, 1H,CHarom., J = 7.8 Hz); 7.63 (d, 2H, CHarom., J = 6.9 Hz); 7.95 (bs, 1H, NH); 9.16 (s, 1H, NH); 10.83 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 24.5 (CH2), 44.7 (CH2), 111.3 (C), 111.5 (CH), 118.2 (CH), 118.5 (CH), 120.9 (CH), 122.7 (CH), 126.9 (CH), 127.1 (CH), 127.2 (CH), 128.9 (C), 129.1 (C), 129.4(C), 136.0(C), 136.2 (CH), 181.1 (C). HRMS (ESI) calc. for C17H16ClN3S [M − H]−: 328.8470, found: 328.8467.
1-(2-(1H-Indol-3-yl)ethyl)-3-(3-chlorophenyl)thiourea (14). Yield 85%. m.p. 169–171 °C. 1H-NMR (DMSO-d6) δ (ppm): 2.98 (t, 2H, CH2, J = 7.5 Hz); 3.77 (q, 2H, CH2, J = 5.7 Hz); 6.98 (t, 1H, CHarom., J = 8.1 Hz); 7.04–7.14 (m, 2H, CHarom.); 7.18 (d, 1H, CHarom., J = 2.4 Hz); 7.23–7.36 (m, 3H, CHarom.); 7.63 (d, 2H, CHarom., J = 8.4 Hz); 7.91 (bs, 1H, NH); 9.65 (s, 1H, NH); 10.84 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 24.4 (CH2), 44.5 (CH2), 111.4 (C), 111.5 (CH), 118.2 (CH, CH), 118.5 (CH), 120.96 (CH), 122.0 (CH), 122.8 (CH), 123.4 (CH), 127.2 (C), 130.1 (C), 132.6 (C), 136.3 (C), 140.9 (CH), 180.1 (C). HRMS (ESI) calc. for C17H16ClN3S [M − H]−: 328.8470, found: 328.8468.
1-(2-(1H-Indol-3-yl)ethyl)-3-(2-bromophenyl)thiourea (15). Yield 83%. m.p. 150–152 °C. 1H-NMR (DMSO-d6) δ (ppm): 2.98 (t, 2H, CH2, J = 7.2 Hz); 3.75 (q, 2H, CH2, J = 5.4 Hz); 6.98 (t, 1H,CHarom., J = 7.8 Hz); 7.07 (t, 1H, CHarom., J = 6.6 Hz); 7.12–7.17 (m, 2H, CHarom.); 7.32–7.38 (m, 2H, CHarom.); 7.57 (d, 1H, CHarom., J = 7.2 Hz); 7.62–7.66 (m, 2H, CHarom.); 7.91 (bs, 1H, NH); 9.11 (s, 1H, NH); 10.83 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 24.5 (CH2), 44.7 (CH2), 111.3 (C), 111.5 (CH), 118.2 (CH), 118.5 (CH), 120.2 (CH), 120.9 (CH), 122.8 (CH), 127.2 (CH), 127.4 (CH), 127.7 (C), 129.7 (C), 132.5 (C), 136.2 (C), 137.4 (CH), 181.1 (C). HRMS (ESI) calc. for C17H16BrN3S [M − H]−: 373.2980, found: 373.2978.
1-(2-(1H-Indol-3-yl)ethyl)-3-phenethylthiourea (
16). This compound was synthesized as described previously [
44].
1-(2-(1H-Indol-3-yl)ethyl)-3-(4-fluorophenyl)thiourea (
17). This compound was synthesized as described previously [
42].
1-(2-(1H-Indol-3-yl)ethyl)-3-allylthiourea (
18). This compound was synthesized as described previously [
40].
1-(2-(1H-Indol-3-yl)ethyl)-3-(2-methylallyl)thiourea (19). Yield 76%. m.p. 141–143 °C. 1H-NMR (DMSO-d6) δ (ppm): 1.67 (s, 3H, CH3); 2.90 (t, 2H, CH2, J = 7.2 Hz); 3.67 (bs, 2H, CH2); 3.98 (bs, 2H, CH2); 4.77 (s, 2H, =CH2); 6.98 (t, 1H, CHarom., J = 7.8 Hz); 7.08 (t, 1H, CHarom., J = 6.9 Hz); 7.14 (d, 1H, CHarom., J = 2.4 Hz); 7.33 (d, 1H, CHarom., J = 8.1 Hz); 7.42 (bs, 1H, NH); 7.56 (bs, 1H, NH); 7.59 (d, 1H, CHarom., J = 7.8 Hz); 10.82 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 20.3 (CH3), 24.9 (CH2), 44.4 (C), 48.7 (CH2), 109.9 (CH2), 111.3 (CH2), 111.6 (C), 118.2 (CH), 118.46 (CH), 120.9 (CH), 122.7 (CH), 127.3 (C), 136.2 (C), 142.4 (CH), 182.5 (C). HRMS (ESI) calc. for C15H19N3S [M − H]−: 272.3964, found: 272.3486.
1-(2-(1H-Indol-3-yl)ethyl)-3-ethoxycarbonylthiourea (
20). This compound was synthesized as described previously [
43].
1-(2-(1H-Indol-3-yl)ethyl)-3-(4-iodophenyl)thiourea (21). Yield 88%. m.p. 162–165 °C. 1H-NMR (DMSO-d6) δ (ppm): 2.97 (t, 2H, CH2, J = 7.5 Hz); 3.75 (q, 2H, CH2, J = 6.0 Hz); 6.98 (t, 1H, CHarom., J = 6.9 Hz); 7.07 (t, 1H,CHarom., J = 6.9 Hz); 7.20 (m, 3H, CHarom.); 7.34 (d, 1H, CHarom., J = 8.1 Hz); 7.61 (m, 3H, CHarom.); 7.83 (bs, 1H, NH); 9.57 (s, 1H, NH); 10.84 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 24.39 (CH2), 44.53 (CH2), 111.34 (C), 111.48 (CH), 118.22 (CH, CH), 118.46 (CH), 120.95 (CH, CH), 122.81 (CH), 124.92 (CH), 127.21 (CH), 136.26 (C), 137.13 (C, C), 139.18 (CH), 180.03 (C). HRMS (ESI) calc. for C17H16IN3S [M − H]−: 420.2985, found: 420.2987.
1-(2-(1H-Indol-3-yl)ethyl)-3-ethylthiourea (
22). This compound was synthesized as described previously [
45].
1-(2-(1H-Indol-3-yl)ethyl)-3-(3-chloro-4-methylphenyl)thiourea (23). Yield 83%. m.p. 161–163 °C. 1H-NMR (DMSO-d6) δ (ppm): 2.28 (s, 3H, CH3); 2.98 (t, 2H, CH2, J = 7.5 Hz); 3.76 (q, 2H, CH2, J = 5.7 Hz); 6.98 (t, 1H, CHarom., J = 8.1 Hz); 7.08 (t, 1H, CHarom., J = 6.9 Hz); 7.13–7.18 (m, 2H, CHarom.); 7.25 (d, 1H, CHarom., J = 8.4 Hz); 7.34 (d, 1H,CHarom., J = 7.8 Hz); 7.57 (d, 1H,CHarom., J = 2.1 Hz); 7.62 (d, 1H, CHarom., J = 7.5 Hz); 7.81 (bs, 1H, NH); 9.55 (s, 1H, NH); 10.84 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 18.9 (CH3), 24.4 (CH2), 44.5 (CH2), 111.3 (C), 111.5 (CH), 118.2 (CH), 118.5 (CH), 120.9 (CH), 121.7 (CH), 122.8 (C), 123.0 (CH), 127.2 (CH), 130.7 (C), 130.9 (C), 132.6 (C), 136.3 (C), 138.4 (CH), 180.2 (C). HRMS (ESI) calc. for C18H18ClN3S [M − H]−: 342.8736, found: 342.8769.
1-(2-(1H-Indol-3-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)thiourea (24). Yield 92%. m.p. 169–171 °C. 1H-NMR (DMSO-d6) δ (ppm): 2.99 (t, 2H, CH2, J = 7.2 Hz); 3.79 (q, 2H, CH2, J = 5.7 Hz); 6.98 (t, 1H, CHarom., J = 7.8 Hz); 7.08 (t, 1H, CHarom., J = 7.8 Hz); 7.18 (d, 1H,CHarom., J = 2.1 Hz); 7.35 (d, 1H, CHarom., J = 8.1 Hz); 7.40 (d, 1H, CHarom., J = 7.8 Hz); 7.50 (d, 1H, CHarom., J = 7.8 Hz); 7.64 (d, 1H, CHarom., J = 7.8 Hz); 7.98 (s, 1H, CHarom.); 7.98 (bs, 1H, NH); 9.79 (s, 1H, NH); 10.85 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 24.4 (CH2), 44.4 (CH2), 79.2 (C), 111.4 (C), 111.4 (CH), 118.2 (CH), 118.4 (CH), 118.6 (CH), 121.0 (q, 3.8 Hz, CH), 122.8 (q, J = 3.8 Hz, CH), 125.8 (q, J = 272 Hz, C), 126.1 (CH), 127.2 (CH), 128.8 (C), 129.5 (q, J = 33.6 Hz, C), 136.3 (C), 140.4, 180.4 (C). HRMS (ESI) calc. for C18H16F3N3S [M − H]−: 362.3999, found: 362.3940.
1-(2-(1H-Indol-3-yl)ethyl)-3-methylthiourea (
25). This compound was synthesized as described previously [
46].
1-(2-(1H-Indol-3-yl)ethyl)-3-(3-chloro-6-methylphenyl)thiourea (26). Yield 87%. m.p. 163–165 °C. 1H-NMR (DMSO-d6) δ (ppm): 2.13 (s, 3H, CH3); 2.96 (t, 2H, CH2, J = 7.2 Hz); 3.73 (q, 2H, CH2, J = 5.1 Hz); 6.98 (t, 1H,CHarom., J = 6.3 Hz); 7.07 (t, 1H, CHarom., J = 6.9 Hz); 7.15–7.26 (m, 3H, CHarom.); 7.34 (d, 1H, CHarom., J = 8.1 Hz); 7.37 (s, 1H, CHarom.); 7.63 (d, 1H, CHarom., J = 7.8 Hz); 7.71 (bs, 1H, NH); 9.11 (s, 1H, NH); 10.82 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 17.2 (CH3), 24.6 (CH2), 44.8 (CH2), 111.3 (C), 111.6 (CH), 118.2 (CH), 118.5 (CH), 120.9 (CH), 122.7 (CH), 125.8 (C), 127.0 (CH), 127.3 (CH), 129.7 (C), 131.8 (C), 133.1 (C), 136.2 (C), 138.6 (CH), 180.9 (C). HRMS (ESI) calc. for C18H18ClN3S [M − H]−: 342.8736, found: 342.8772.
1-(2-(1H-Indol-3-yl)ethyl)-3-(4-butyl-2-methylphenyl)thiourea (27). Yield 77%. m.p. 172–174 °C. 1H-NMR (DMSO-d6) δ (ppm): 0.8 (t, 3H, CH3, J = 7.5 Hz); 1.25–1.37 (m, 2H, CH2, J = 7.5 Hz); 1.49–1.59 (m, 2H, CH2, J = 7.2 Hz); 2.11 (s, 3H, CH3); 2.49 (s, 2H, CH2); 2.93 (t, 2H, CH2, J = 7.5 Hz); 3.69 (q, 2H, CH2, J = 6.0 Hz); 6.94–7.11 (m, 6H, CHarom.); 7.25 (bs, 1H, NH); 7.33 (d, 1H, CHarom., J = 8.1 Hz); 7.63 (d, 1H, CHarom., J = 7.8 Hz); 9.01 (s, 1H, NH); 10.79 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 13.8 (CH3), 17.6 (CH2), 21.8 (CH2), 24.8 (CH3), 33.0 (CH2), 34.3 (CH2), 40.3 (CH2), 111.3 (C), 111.6 (CH), 118.1 (CH), 118.5 (CH), 120.9 (CH, CH), 122.6 (C), 126.2 (C), 127.3 (CH), 127.6 (CH), 130.4 (C), 134.5 (C), 136.2 (C), 140.6, 180.8 (C). HRMS (ESI) calc. for C22H27N3S [M − H]−: 364.5348, found: 364.5360.
1-(2-(1H-Indol-3-yl)ethyl)-3-(3-chloro-4-fluorophenyl)thiourea (28). Yield 91%. m.p. 162–164 °C. 1H-NMR (DMSO-d6) δ (ppm): 2.98 (t, 2H, CH2, J = 7.2 Hz); 3.76 (q, 2H, CH2, J = 5.7 Hz); 6.98 (t, 1H, CHarom., J = 8.1 Hz); 7.08 (t, 1H,CHarom., J = 7.2 Hz); 7.18 (d, 1H, CHarom., J = 2.1 Hz); 7.24–7.30 (m, 1H, CHarom.); 7.34 (d, 2H,CHarom., J = 8.7 Hz); 7.62 (d, 1H,CHarom., J = 7.8 Hz); 7.72 (d, 1H, CHarom., J = 6.6 Hz); 7.87 (bs, 1H, NH); 9.60 (s, 1H, NH); 10.84 (s, 1H, NH). 13C-NMR (DMSO-d6) δ (ppm): 24.4 (CH2), 44.5 (CH2), 111.4 (C), 111.5 (CH), 116.6 (d, J = 22 Hz, CH), 118.2 (CH), 118.4 (d, J = 18.6 Hz, CH), 121.0 (CH), 122.8 (CH), 123.6 (CH), 124.9 (d, J = 7.2 Hz, C), 127.2 (C), 136.3 (C), 136.5 (d, J = 3.3 Hz, C), 152.2 (C), 155.5 (d, J = 242.6 Hz, CH), 180.4 (C). HRMS (ESI) calc. for C17H15ClFN3S [M − H]−: 346.8375, found: 346.8378. Crystal data: crystal system triclinic, space group P-1, unit cell dimensions a = 8.592(2) Å, b = 12.4914(3) Å, c = 15.309(3) Å, α = 85.32(2)°, β = 81.17(2)°, γ = 88.87(2)°, V = 1678.1(6) Å3; Z = 4, dc = 1.428 g/cm3, μ = 0.377 mm−1, F(000) = 720. A crystal of dimensions 0.40 × 0.20 × 0.03 mm was used for intensity measurements. Within the θ range 2.04–28.54° [−11 ≤ h ≤ 11, −16 ≤ k ≤ 16, −20 ≤ l ≤ 20], reflections collected 22058. The 5859 unique reflections [R(int) = 0.0360] were used for the refinement of 427 parameters. Final R indices on F2 for 5698 observed reflections [I > 2σ(I)] were: R1 = 0.0483, wR2 = 0.1019, goodness-of-fit 1.018, Δρmax/min = 0.76/−0.80 e Å−3.