Nematicidal Activity of 3-Acyltetramic Acid Analogues Against Pine Wood Nematode, Bursaphelenchus xylophilus
AbstractAmong 98 3-acyltetramic acid analogues, compounds 1c, 2c, 2f and 2g, showed >90% nematicidal activity against the pine wood nematode Bursaphelenchus xylophilus at a 10 μg/mL concentration. The nematicidal activities of compounds 1d, 1h, and 2k were a little lower at 88.0%, 85.8%, and 57.2% at a 10 μg/mL concentration, respectively. The nematicidal activity of emamection benzoate, widely used in Korea for the prevention of pine wilt disease, was 32.3% at a 10 μg/mL concentration. Other 3-acyltetramic acid analogues showed less than 30% nematicidal activity. A structure-activity relationship study indicated that the chain length of the C-acyl substituent was very important for high nematicidal activity. All active compounds had C13H27 or C11H23 acyl substituents, in two closely related groups with the common physicochemical properties of a polar surface area 57.6A2, PSA (polar surface area) 7.8–8.6% and ClogP (calculated partition coefficient) 5.1–5.9 and a polar surface area 75–84A2, PSA 11.1–11.6% and ClogP 4.7–5.1, respectively. Our study indicates that active 3-acyltetramic acid analogues could have potential as lead compounds for developing novel pine wood nematode control agents. View Full-Text
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Lee, H.-R.; Lee, S.-C.; Lee, J.-E.; Seo, S.-M.; Jeong, Y.-C.; Jung, C.-S.; Moloney, M.G.; Park, I.-K. Nematicidal Activity of 3-Acyltetramic Acid Analogues Against Pine Wood Nematode, Bursaphelenchus xylophilus. Molecules 2017, 22, 1568.
Lee H-R, Lee S-C, Lee J-E, Seo S-M, Jeong Y-C, Jung C-S, Moloney MG, Park I-K. Nematicidal Activity of 3-Acyltetramic Acid Analogues Against Pine Wood Nematode, Bursaphelenchus xylophilus. Molecules. 2017; 22(9):1568.Chicago/Turabian Style
Lee, Hyo-Rim; Lee, Sung-Chan; Lee, Ji-Eun; Seo, Seon-Mi; Jeong, Yong-Chul; Jung, Chan-Sik; Moloney, Mark G.; Park, Il-Kwon. 2017. "Nematicidal Activity of 3-Acyltetramic Acid Analogues Against Pine Wood Nematode, Bursaphelenchus xylophilus." Molecules 22, no. 9: 1568.
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