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Molecules 2017, 22(9), 1447; doi:10.3390/molecules22091447

Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery

Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea
These authors contributed equally to this work.
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Received: 31 July 2017 / Accepted: 27 August 2017 / Published: 31 August 2017
(This article belongs to the Special Issue Recent Advances in Biomolecular NMR Spectroscopy)
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Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which triggers severe pulmonary diseases. Recently, multidrug/extensively drug-resistant tuberculosis strains have emerged and continue to threaten global health. Because of the development of drug-resistant tuberculosis, there is an urgent need for novel antibiotics to treat these drug-resistant bacteria. In light of the clinical importance of M. tuberculosis, 2067 structures of M. tuberculsosis proteins have been determined. Among them, 52 structures have been solved and studied using solution nuclear magnetic resonance (NMR). The functional details based on structural analysis of M. tuberculosis using NMR can provide essential biochemical data for the development of novel antibiotic drugs. In this review, we introduce diverse structural and biochemical studies on M. tuberculosis proteins determined using NMR spectroscopy. View Full-Text
Keywords: Mycobacterium tuberculosis; antibiotic target; nuclear magnetic resonance (NMR); biomolecular interaction Mycobacterium tuberculosis; antibiotic target; nuclear magnetic resonance (NMR); biomolecular interaction
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Kim, D.-H.; Kang, S.-M.; Lee, B.-J. Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery. Molecules 2017, 22, 1447.

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