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Molecules 2017, 22(9), 1435; doi:10.3390/molecules22091435

Cytotoxic Activity of Origanum Vulgare L. on Hepatocellular Carcinoma cell Line HepG2 and Evaluation of its Biological Activity

1
School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Potenza 85100, Italy
2
Department of Sciences, University of Basilicata, Potenza 85100, Italy
3
Department of Pharmacy, University of Salerno, Salerno 84084, Italy
*
Author to whom correspondence should be addressed.
Received: 1 August 2017 / Revised: 22 August 2017 / Accepted: 29 August 2017 / Published: 30 August 2017
(This article belongs to the Special Issue Natural Products: Anticancer Potential and Beyond)
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Abstract

The potential of plant essential oils (EOs) in anticancer treatment has recently received many research efforts to overcome the development of multidrug resistance and their negative side effects. The aims of the current research are to study (i) the cytotoxic effect of the crude EO extracted from Origanum vulgare subsp hirtum and its main constituents (carvacrol, thymol, citral and limonene) on hepatocarcinoma HepG2 and healthy human renal cells HEK293; (ii) the antibacterial and phytotoxic activities of the above EO and its main constituents. Results showed that cell viability percentage of treated HepG2 by EO and its main constituents was significantly decreased when compared to untreated cells. The calculated inhibition concentration (IC50) values for HepG2 were lower than healthy renal cells, indicating the sort of selectivity of the studied substances. Citral is not potentially recommended as an anticancer therapeutic agent, since there are no significant differences between IC50 values against both tested cell lines. Results showed also that oregano EO and its main constituents have a significant antibacterial activity and a moderate phytotoxic effect. The current research verified that oregano EO and its main constituents could be potentially utilized as anticancer therapeutic agents. View Full-Text
Keywords: anticancer therapeutic agents; GC-MS analysis; liver tumor cell line; renal cell line; antibacterial activity; phytotoxic activity anticancer therapeutic agents; GC-MS analysis; liver tumor cell line; renal cell line; antibacterial activity; phytotoxic activity
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MDPI and ACS Style

Elshafie, H.S.; Armentano, M.F.; Carmosino, M.; Bufo, S.A.; De Feo, V.; Camele, I. Cytotoxic Activity of Origanum Vulgare L. on Hepatocellular Carcinoma cell Line HepG2 and Evaluation of its Biological Activity. Molecules 2017, 22, 1435.

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