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Molecules 2017, 22(4), 644; doi:10.3390/molecules22040644

Systematic Understanding of the Mechanism of Salvianolic Acid A via Computational Target Fishing

Department of Traditional Chinese Medicine, Zhejiang Pharmaceutical College, 888 Yinxian Avenue Eastern Section, Ningbo 315100, China
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Academic Editor: Derek J. McPhee
Received: 6 March 2017 / Revised: 8 April 2017 / Accepted: 12 April 2017 / Published: 17 April 2017
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Abstract

Salvianolic acid A (SAA) is one of the most abundant water-soluble and potent anti-oxidative compounds isolated from Danshen, a traditional Chinese medicine. A systematic overview of its mechanism of action is yet to be performed. In the present study, the druggability of SAA was measured using the TCMSP server, and potential targets of SAA were identified by PharmMapper and DRAR-CPI. Intersecting targets were then assessed by GeneMANIA and GO pathway analysis, and drug-target-pathway networks were constructed to give a visual view. The results showed that SAA has good druggability, and 13 putative protein targets were identified. Network analysis showed that these targets were associated with cancer, metabolism and other physiological processes. In summary, SAA is predicted to target multiple proteins and pathways to form a network that exerts systematic pharmacological effects. View Full-Text
Keywords: Danshen; druggability; network pharmacology; salvianolic acid A; target fishing Danshen; druggability; network pharmacology; salvianolic acid A; target fishing
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Chen, S.-J.; Cui, M.-C. Systematic Understanding of the Mechanism of Salvianolic Acid A via Computational Target Fishing. Molecules 2017, 22, 644.

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