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Molecules 2017, 22(4), 639; doi:10.3390/molecules22040639

Evaluation of Polyphenolic Content, Antioxidant and Diuretic Activities of Six Fumaria Species

1
Department of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
2
ICHAT and Institute for Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania
3
Department of Pharmaceutical Technology and Biopharmaceutics, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400010 Cluj-Napoca, Romania
4
Department of Pharmacology, Physiology and Physiopathology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania
5
Department of Organic Chemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400010 Cluj-Napoca, Romania
These authors have equal contributions
*
Author to whom correspondence should be addressed.
Academic Editor: Christian Zidorn
Received: 20 February 2017 / Revised: 7 April 2017 / Accepted: 8 April 2017 / Published: 15 April 2017
(This article belongs to the Section Natural Products)
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Abstract

Romanian traditional medicine describes the use of aerial parts of Fumaria species to treat hepatobiliary diseases as well as diuretic agents. The present study aims to investigate the chemical composition, antioxidant properties, and diuretic effects of several Fumaria species. LC/MS analysis revealed that Fumaria species contain phenolic acids and high amounts of flavonoids with rutin and isoquercitrin as main compounds. Concerning antioxidant capacity, the most significant results were obtained for F. capreolata and F. vailantii. Both species showed a good correlation between the antioxidant capacity and a high amount of flavonoids. Furthermore, the extracts of F. officinalis and F. schleicheri produced a strong increase in urinary volumetric excretion of saline-loaded rats, 24 h after the oral administration of a single dose of 250 mg/kg bw. Moreover, both extracts of F. officinalis and F. schleicheri increased the urinary excretion of Na+ and K+. Results from the present study offer a new perspective concerning the chemical composition and bioactivities of traditionally used fumitory species. View Full-Text
Keywords: Fumaria genus; LC-MS; polyphenols; antioxidants; diuretic activity Fumaria genus; LC-MS; polyphenols; antioxidants; diuretic activity
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MDPI and ACS Style

Păltinean, R.; Mocan, A.; Vlase, L.; Gheldiu, A.-M.; Crișan, G.; Ielciu, I.; Voștinaru, O.; Crișan, O. Evaluation of Polyphenolic Content, Antioxidant and Diuretic Activities of Six Fumaria Species. Molecules 2017, 22, 639.

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