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Molecules 2017, 22(4), 587; doi:10.3390/molecules22040587

Fraxin Prevents Chemically Induced Hepatotoxicity by Reducing Oxidative Stress

1
Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 54538, Korea
2
College of Pharmacy, Pusan National University, San 30, Jangjeon-dong, Busan 46241, Korea
3
Dongbu Eastern Herbal Medicine Agricultural Association Corporation, Yeosunro 1679, Sunchun-si, Jeonnam 58019, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Dong-Kug Choi and Palanivel Ganesan
Received: 31 January 2017 / Revised: 3 April 2017 / Accepted: 4 April 2017 / Published: 6 April 2017
(This article belongs to the Special Issue Natural Products and Chronic Diseases)
View Full-Text   |   Download PDF [2777 KB, uploaded 6 April 2017]   |  

Abstract

Fraxin isolated from Acer tegmentosum is reported to exert potent anti-oxidative stress action. However, pharmacological activities of fraxin remain to be elucidated. This study investigated the potential hepatoprotective effects of fraxin and the underlying signaling mechanism involved. Treatment with fraxin significantly lowered the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a CCl4-induced hepatotoxicity rat model. In the fraxin-treated group, glutathione (GSH) significantly increased, while the malondialdehyde (MDA) in the liver significantly decreased. Fraxin also showed radical-scavenging activity. Furthermore, it significantly reduced the t-BHP-induced cytotoxicity and production of reactive oxygen species (ROS) in Hep G2. Fraxin protected Hep G2 cells through Nrf2 pathway-dependent HO-1 expression. The results of this study indicate that fraxin shows potent hepatoprotective effects in vitro and in vivo, presumably through direct antioxidant activity and the Nrf2-mediated antioxidant enzyme system. View Full-Text
Keywords: antioxidant; A. tegmentosum; fraxin; hepatoprotective; HO-1; Nrf2 antioxidant; A. tegmentosum; fraxin; hepatoprotective; HO-1; Nrf2
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MDPI and ACS Style

Chang, B.Y.; Jung, Y.S.; Yoon, C.-S.; Oh, J.S.; Hong, J.H.; Kim, Y.-C.; Kim, S.Y. Fraxin Prevents Chemically Induced Hepatotoxicity by Reducing Oxidative Stress. Molecules 2017, 22, 587.

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