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Molecules 2017, 22(4), 575; doi:10.3390/molecules22040575

Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens

1
Department of Oncology, Henan Academy institute of Traditional Chinese Medicine, Zhengzhou 450000, Henan, China
2
Department of Traditional Chinese Medicine, Henan Province People's Hospital, Zhengzhou 450002, Henan, China
*
Author to whom correspondence should be addressed.
Received: 5 February 2017 / Revised: 29 March 2017 / Accepted: 30 March 2017 / Published: 1 April 2017
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Abstract

A simple and sensitive electrochemical sensor fabricated with graphene nanosheets (GNs) and a hydroxyapatite (HA) nanocomposite–modified glassy carbon electrode (GCE) was developed for the determination of matrine (MT). The as-prepared electrode (GNs/HA/GCE) was verified to outperform bare a GCE and GNs-modified electrode with increased oxidation peak currents and the decreased over-potential in the redox process of MT, indicating the great enhancement of electrocatalytic activity toward the oxidation of MT by the composite of GNs and HA. Under the optimized conditions, the oxidation peak currents were related linearly with the concentration of MT, ranging from 2 μM to 3 mM, and the detection limit (S/N = 3) was 1.2 μM. In addition, the proposed electrochemical sensor can be successfully applied in the quantitative determination of MT in Sophora flavescens extract. View Full-Text
Keywords: matrine; voltammetric sensors; Sophora flavescens; electrochemistry; hydroxyapatite matrine; voltammetric sensors; Sophora flavescens; electrochemistry; hydroxyapatite
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Zhang, J.; Wang, Y.; Zheng, W. Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens. Molecules 2017, 22, 575.

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