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Molecules 2017, 22(4), 540; doi:10.3390/molecules22040540

Bioactive Constituents Obtained from the Seeds of Lepidium apetalum Willd

1
Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
2
Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 25 January 2017 / Revised: 24 March 2017 / Accepted: 25 March 2017 / Published: 28 March 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1295 KB, uploaded 30 March 2017]   |  

Abstract

Three new compounds, apetalumosides C1 (1), D (2), and 1-thio--d-glucopyranosyl(1→1)-1-thio-α-d-glucopyranoside (3), together with twenty-two known ones (4–25) were obtained from the seeds of Lepidium apetalum Willd. Among the known isolates, 58, 1013, 1620, and 25 were obtained from the genus for the first time; 4, 14, 15, and 2124 were isolated from the species for the first time. Meanwhile, the NMR data of 16 was first reported here. Their structures were determined by means of chemical and spectroscopic methods. On the other hand, their inhibitory effects on sodium oleate-induced triglyceride (TG) overloading in HepG2 cells were evaluated. As a result, two new compounds (1 and 2), together with known isolates 7–11, 13, 14, 16–18, 20, 21, and 25 possessed significant inhibitory effects in the cells. View Full-Text
Keywords: Lepidium apetalum; flavonoid glycosides; phenolic glycosides; HepG2 cells; triglyceride accumulation inhibitory effects Lepidium apetalum; flavonoid glycosides; phenolic glycosides; HepG2 cells; triglyceride accumulation inhibitory effects
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Wang, S.; Shi, P.; Qu, L.; Ruan, J.; Yang, S.; Yu, H.; Zhang, Y.; Wang, T. Bioactive Constituents Obtained from the Seeds of Lepidium apetalum Willd. Molecules 2017, 22, 540.

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