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Molecules 2017, 22(12), 2097; doi:10.3390/molecules22122097

Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates

1
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
*
Author to whom correspondence should be addressed.
Received: 20 October 2017 / Revised: 24 November 2017 / Accepted: 28 November 2017 / Published: 29 November 2017
(This article belongs to the Special Issue Organometallic Catalysis in Organic Synthesis)
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Abstract

Given the importance of heterocycle indole derivatives, much effort has been directed toward the development of methods for functionalization of the indole nucleus at N1 and C3 sites. Moreover, the platinum-catalyzed allyation of nucleophiles was an established and efficient way, which has been applied to medicinal and organic chemistry. In our research, the platinum-catalyzed 2,3-disubstitued indoles with allylic acetates was investigated under different conditions. Herein, we established a simple, convenient, and efficient method, which afforded high yield of allylated indoles. View Full-Text
Keywords: platinum-catalyzed; indole derivatives; allylic acetates; allylation platinum-catalyzed; indole derivatives; allylic acetates; allylation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Peng, B.-J.; Wu, W.-T.; Yang, S.-C. Platinum-Catalyzed Allylation of 2,3-Disubstituted Indoles with Allylic Acetates. Molecules 2017, 22, 2097.

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