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Molecules 2017, 22(11), 2040; doi:10.3390/molecules22112040

Solid Lipid Nanoparticles of Albendazole for Enhancing Cellular Uptake and Cytotoxicity against U-87 MG Glioma Cell Lines

1
Chinese-German Joint Laboratory for Natural Product Research, Qinling-Bashan Mountains Bioresources Comprehensive Development C.I.C., College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China
2
Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, Tamilnadu, 641004, India
3
Department of Translational Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro 66030, Italy
4
Department of Integrative Plant Biology, Institute of Plant Genetics of the Polish Academy of Sciences, Strzeszyńska 34, 60-479 Poznań, Wielkopolska, Poland
*
Authors to whom correspondence should be addressed.
Received: 27 October 2017 / Revised: 14 November 2017 / Accepted: 21 November 2017 / Published: 22 November 2017
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Abstract

Albendazole (ABZ) is an antihelminthic drug used for the treatment of several parasitic infestations. In addition to this, there are reports on the anticancer activity of ABZ against a wide range of cancer types. However, its effect on glioma has not yet been reported. In the present study, cytotoxicity of ABZ and ABZ loaded solid lipid nanoparticles (ASLNs) was tested in human glioma/astrocytoma cell line (U-87 MG). Using glyceryl trimyristate as lipid carrier and tween 80 as surfactant spherical ASLNs with an average size of 218.4 ± 5.1 nm were prepared by a combination of high shear homogenization and probe sonication methods. A biphasic in vitro release pattern of ABZ from ASLNs was observed, where 82% of ABZ was released in 24 h. In vitro cell line studies have shown that ABZ in the form of ASLNs was more cytotoxic (IC50 = 4.90 µg/mL) to U-87 MG cells compared to ABZ in the free form (IC50 = 13.30 µg/mL) due to the efficient uptake of the former by these cells. View Full-Text
Keywords: albendazole; solid lipid nanoparticles; U-87 MG cells; cytotoxicity; cellular uptake albendazole; solid lipid nanoparticles; U-87 MG cells; cytotoxicity; cellular uptake
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Marslin, G.; Siram, K.; Liu, X.; Khandelwal, V.K.M.; Shen, X.; Wang, X.; Franklin, G. Solid Lipid Nanoparticles of Albendazole for Enhancing Cellular Uptake and Cytotoxicity against U-87 MG Glioma Cell Lines. Molecules 2017, 22, 2040.

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