Synthesis of Spironucleosides: Past and Future Perspectives
AbstractSpironucleosides are a type of conformationally restricted nucleoside analogs in which the anomeric carbon belongs simultaneously to the sugar moiety and to the base unit. This locks the nucleic base in a specific orientation around the N-glycosidic bond, imposing restrictions on the flexibility of the sugar moiety. Anomeric spiro-functionalized nucleosides have gained considerable importance with the discovery of hydantocidin, a natural spironucleoside isolated from fermentation broths of Streptomyces hygroscopicus which exhibits potent herbicidal activity. The biological activity of hydantocidin has prompted considerable synthetic interest in this nucleoside and also in a variety of analogues, since important pharmaceutical leads can be found among modified nucleoside analogues. We present here an overview of the most important advances in the synthesis of spironucleosides. View Full-Text
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Soengas, R.G.; da Silva, G.; Estévez, J.C. Synthesis of Spironucleosides: Past and Future Perspectives. Molecules 2017, 22, 2028.
Soengas RG, da Silva G, Estévez JC. Synthesis of Spironucleosides: Past and Future Perspectives. Molecules. 2017; 22(11):2028.Chicago/Turabian Style
Soengas, Raquel G.; da Silva, Gustavo; Estévez, Juan C. 2017. "Synthesis of Spironucleosides: Past and Future Perspectives." Molecules 22, no. 11: 2028.
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