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Molecules 2017, 22(11), 2013; doi:10.3390/molecules22112013

Anti-Bacterial and Microecosystem-Regulating Effects of Dental Implant Coated with Dimethylaminododecyl Methacrylate

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State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China
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National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610041, China
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Department of Cariology and Endodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China
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National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
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Department of Advanced Oral Sciences & Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA
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Authors to whom correspondence should be addressed.
Received: 25 October 2017 / Accepted: 15 November 2017 / Published: 20 November 2017
(This article belongs to the Special Issue Antibacterial Materials and Coatings)
View Full-Text   |   Download PDF [13651 KB, uploaded 22 November 2017]   |  

Abstract

The effects of dimethylaminododecyl methacrylate (DMADDM) modified titanium implants on bacterial activity and microbial ecosystem of saliva-derived biofilm were investigated for the first time. Titanium discs were coated with DMADDM solutions at mass fractions of 0 mg/mL (control), 1, 5 and 10 mg/mL, respectively. Biomass accumulation and metabolic activity of biofilms were tested using crystal violet assay and MTT (3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. 16S rRNA gene sequencing was performed to measure the microbial community. Live/dead staining and scanning electron microscopy (SEM) were used to value the structure of biofilm. The results showed that the higher mass fraction of DMADDM the coating solution had, the significantly lower the values of metabolic activity and accumulated biofilms got, as well as fewer live cells and less extracellular matrix. Moreover, 5 mg/mL of DMADDM was the most effective concentration, as well as 10 mg/mL. In microecosystem-regulation, the DMADDM modified titanium implant decreased the relative abundance of Neisseria and Actinomyces and increased the relative abundance of Lactobacillus, a probiotic for peri-implant diseases. In conclusion, via inhibiting growth and regulating microecosystem of biofilm, this novel titanium implant coating with DMADDM was promising in preventing peri-implant disease in an ‘ecological manner’. View Full-Text
Keywords: dental implant; peri-implant diseases; dimethylaminododecyl methacrylate; antimocrobial material; saliva-derived biofilm dental implant; peri-implant diseases; dimethylaminododecyl methacrylate; antimocrobial material; saliva-derived biofilm
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MDPI and ACS Style

Li, B.; Ge, Y.; Wu, Y.; Chen, J.; Xu, H.H.K.; Yang, M.; Li, M.; Ren, B.; Feng, M.; Weir, M.D.; Peng, X.; Cheng, L.; Zhou, X. Anti-Bacterial and Microecosystem-Regulating Effects of Dental Implant Coated with Dimethylaminododecyl Methacrylate. Molecules 2017, 22, 2013.

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