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Molecules 2017, 22(11), 1998; doi:10.3390/molecules22111998

Neuraminidase Inhibitory Activity and Constituent Characterization of Fagopyrum dibotrys

1
Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China
2
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
*
Authors to whom correspondence should be addressed.
Received: 21 October 2017 / Revised: 8 November 2017 / Accepted: 15 November 2017 / Published: 18 November 2017
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Abstract

This study aimed to identify a new biological activity of the widely distributed species Fagopyrum dibotrys. Four F. dibotrys extracts (ethyl acetate (EA), petroleum ether (P), ethanol (E), and water (W)) were explored for their anti-neuraminidase (NA) activity. A total of 32 compounds were identified using UHPLC-Q-Exactive Orbitrap HRMS in the EA extract, which had the best NA inhibitory effects. We used the docking data for supporting compounds’ anti-neuraminidase activity. Among them, five compounds including one flavonoid, three organic acids, and one glucoside were discovered for the first time in F. dibotrys. Docking studies and NA activity assay revealed the remarkable NA inhibitory activity of eight components in EA extract, especially rutin, hesperidin, procyanidin B2, and quercitrin. Therefore, F. dibotrys could be used to develop anti-influenza drugs. View Full-Text
Keywords: Fagopyrum dibotrys; NA inhibitory activity; UHPLC-Q-Exactive; molecular docking; chemical constituents Fagopyrum dibotrys; NA inhibitory activity; UHPLC-Q-Exactive; molecular docking; chemical constituents
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhang, X.; Cao, Y.; Li, J.; Liu, A.; Liu, H.; Huang, L. Neuraminidase Inhibitory Activity and Constituent Characterization of Fagopyrum dibotrys. Molecules 2017, 22, 1998.

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