Practical and Sustainable Synthesis of Optically Pure Levocabastine, a H1 Receptor Antagonist
AbstractA practical and sustainable method for the synthesis of levocabastine hydrochloride (1), a H1 receptor antagonist for the treatment of allergic conjunctivitis, that can be applied to the industrial production of the compound has been developed. Substantial improvements over the previously reported procedure are achieved via efficient preparation of an optically active key intermediate (5) without chiral resolution and with a more effective detosylation, which complements the previous procedure. Notably, our process requires no chromatographic purification and provides levocabastine hydrochloride in greater than 99.5% purity in a 14.2% overall yield. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 1840 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Kang, S.K.; Nam, D.H.; Ahn, J.; Lee, J.; Sim, J.; Lee, J.; Suh, Y.-G. Practical and Sustainable Synthesis of Optically Pure Levocabastine, a H1 Receptor Antagonist. Molecules 2017, 22, 1971.
Kang SK, Nam DH, Ahn J, Lee J, Sim J, Lee J, Suh Y-G. Practical and Sustainable Synthesis of Optically Pure Levocabastine, a H1 Receptor Antagonist. Molecules. 2017; 22(11):1971.Chicago/Turabian Style
Kang, Sung K.; Nam, Dong H.; Ahn, Jaeseung; Lee, Jaemin; Sim, Jaehoon; Lee, Jeeyeon; Suh, Young-Ger. 2017. "Practical and Sustainable Synthesis of Optically Pure Levocabastine, a H1 Receptor Antagonist." Molecules 22, no. 11: 1971.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.