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Molecules 2017, 22(11), 1968; doi:10.3390/molecules22111968

The Effects of 4′-Esterified Resveratrol Derivatives on Calcium Dynamics in Breast Cancer Cells

Department of Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT 84602, USA
Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA
Author to whom correspondence should be addressed.
Received: 21 October 2017 / Revised: 7 November 2017 / Accepted: 11 November 2017 / Published: 14 November 2017
(This article belongs to the Section Natural Products)
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Triple-negative breast cancer is a highly aggressive subtype of breast cancer. Frequently, breast cancer cells modulate their calcium signaling pathways to optimize growth. Unique calcium pathways in breast cancer cells could serve as a way to target tumorigenic cells without affecting normal tissue. Resveratrol has previously been shown to activate calcium signaling pathways. We use cell viability, single-cell calcium microscopy, and RT-PCR assays to determine the activity and mechanism of three different 4′-esterified resveratrol derivatives. We demonstrate that two of the derivatives reduce cell viability more effectively than resveratrol in MDA-MB-231 human breast cancer cells. The derivatives also activate similar pro-apoptotic calcium signaling pathways. In particular, the pivalated and butyrated resveratrol derivatives are intriguing putative chemotherapeutics because they are more effective at decreasing cell viability in vitro and inhibiting the plasma membrane Ca2+-ATPase, a protein that is often modulated in breast cancer. View Full-Text
Keywords: resveratrol derivatives; calcium signaling; p53; cell viability; MDA-MB-231 resveratrol derivatives; calcium signaling; p53; cell viability; MDA-MB-231

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Peterson, J.A.; Doughty, H.P.; Eells, A.J.; Johnson, T.A.; Hastings, J.P.; Crowther, C.M.; Andrus, M.B.; Kenealey, J.D. The Effects of 4′-Esterified Resveratrol Derivatives on Calcium Dynamics in Breast Cancer Cells. Molecules 2017, 22, 1968.

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