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Molecules 2017, 22(11), 1931; doi:10.3390/molecules22111931

A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis

1
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China
2
Institute of Medical Information & Library, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 3 Yabao Street, Beijing 100020, China
3
Beijing Institute for Drug Control, 25 Science Park Road, Changping District, Beijing 102206, China
*
Author to whom correspondence should be addressed.
Received: 13 October 2017 / Accepted: 5 November 2017 / Published: 10 November 2017
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Abstract

A new nortriterpenoid, 19(R)-hydroxyl-wuweizidilactone H (1), and a sesquiterpene, (6R)-β-chamigrenic acid (2), together with one known nortriterpenoid, wuweizidilactone H (3), and three known hepatoprotective lignans, micrantherin A (4), gomisin M2 (5) and schizandrin (6) were isolated from the fruit of Schisandra chinensis. Their structures were elucidated by UV, IR, HRESIMS, NMR spectra and X-ray analysis. Among them, the absolute configuration of 2 was confirmed for the first time. In vitro assays, compounds 46 (10 μM) exhibited hepatoprotective activities (survival rate: 44%, 43% and 44%) against damage induced by N-acetyl-p-aminophenol (APAP) in human liver carcinoma (HepG2) cells. View Full-Text
Keywords: Schisandra chinensis; nortriterpenoid; sesquiterpene; lignan; absolute configuration; hepatoprotective activity Schisandra chinensis; nortriterpenoid; sesquiterpene; lignan; absolute configuration; hepatoprotective activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, F.; Zhang, T.; Sun, H.; Gu, H.; Wang, H.; Su, X.; Li, C.; Li, B.; Chen, R.; Kang, J. A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis. Molecules 2017, 22, 1931.

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