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Molecules 2017, 22(11), 1911; doi:10.3390/molecules22111911

Ferulaldehyde Improves the Effect of Methotrexate in Experimental Arthritis

1
Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, Dúbravská Cesta 9, 841 04 Bratislava, Slovakia
2
Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, 832 32 Bratislava, Slovakia
*
Authors to whom correspondence should be addressed.
Received: 30 September 2017 / Accepted: 3 November 2017 / Published: 6 November 2017
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Abstract

Methotrexate (MTX) is still the gold standard for treatment of rheumatoid arthritis (RA). The therapeutic efficacy of low-dose of MTX can be increased by its combination with a natural substance, ferulaldehyde (FRA). The aim of this study was to evaluate the effect FRA and MTX administered alone or in combination in adjuvant arthritis. The disease was induced to Lewis male rats by intradermal injection, which contains a suspension of heat-inactivated Mycobacterium butyricum in incomplete Freund’s adjuvant. The experiment of 28 days included: healthy animals, arthritic animals, arthritic animals with administration of FRA at the oral daily dose of 15 mg/kg, arthritic animals with administration of MTX at the oral dose of 0.3 mg/kg twice a week, and arthritic animals administered with FRA and MTX. FRA in monotherapy decreased significantly only the level of interleukin-1β (IL-1β) and matrix metalloproteinase-9 in plasma. Combination of FRA and low-dose MTX was more effective than MTX alone when comparing body weight, hind paw volume, arthritic score, plasmatic levels of IL-1β, activity of γ-glutamyl transferase, and relative mRNA expression of IL-1β in the spleen. Therefore, the combination treatment was the most effective. The obtained results are interesting for future possible innovative therapy of patients with RA. View Full-Text
Keywords: ferulaldehyde; methotrexate; adjuvant arthritis; combination treatment; rheumatoid arthritis ferulaldehyde; methotrexate; adjuvant arthritis; combination treatment; rheumatoid arthritis
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Slovák, L.; Švík, K.; Mihalová, D.; Tóth, J.; Czigle, S.; Pašková, Ľ.; Bilka, F.; Bauerová, K. Ferulaldehyde Improves the Effect of Methotrexate in Experimental Arthritis. Molecules 2017, 22, 1911.

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