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Molecules 2017, 22(11), 1851; doi:10.3390/molecules22111851

Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties

1
Département de Biologie, Faculté des Sciences de Tunis el Manar, Unité de recherche ‘Nutrition et métabolismes azoté et protéines de stress’ (99 UR/09-20), 1002 Tunis, Tunisia
2
Department of Earth and Environmental Sciences, University of Pavia, Via S. Epifanio 14, 27100 Pavia, Italy
3
Centre for Health Technologies (CHT), University of Pavia, Viale Taramelli 12, Pavia 27100, Italy
4
Indena S.p.A., Via Don Minzoni, 6, 20090 Settala, Italy
5
Centro Grandi Strumenti (CGS), University of Pavia, Via Bassi 21, 27100 Pavia, Italy
6
Department of Drug Sciences, Medicinal Chemistry section, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
*
Authors to whom correspondence should be addressed.
Received: 6 September 2017 / Revised: 13 October 2017 / Accepted: 26 October 2017 / Published: 28 October 2017
(This article belongs to the Collection Herbal Medicine Research)
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Abstract

Several factors contribute in wound generation, e.g., accidental traumas or surgery, and in certain cases, this dermal injury may have a devastating outcome. When skin damage occurs, the human body puts in place a sophisticated choreography, which involves numerous repairing processes to restore physiological conditions. Nevertheless, natural healing mechanisms are ineffective towards chronic or non-healing wounds and thus, therapeutic strategies may represent the only beneficial alternative to counteract these tissue insults. Over the years, numerous studies showed the great potential of plants in promoting wound healing, by virtue of their high contents in antioxidant species. These compounds trigger a molecular cascade that collimate into the promotion of reparative processes. In this article, we report on the potential effect on wound healing of Marrubium vulgare L., a medicinal plant well known for several pharmaceutical activities. To this aim, the methanolic extract was prepared and subjected to a phytochemical investigation, quantifying the amount of marrubiin via NMR and drawing the phytochemical fingerprint via high performance liquid chromatography—ultra violet/photodiode-array detection-electrospray/mass (HPLC-UV/PAD-ESI/MS) analysis. Lastly, the antioxidant properties and wound healing potential have been evaluated. View Full-Text
Keywords: Wound healing; Marrubium vulgare L. leave extract; q-NMR; antioxidant properties; HPLC-UV/PAD MS analysis Wound healing; Marrubium vulgare L. leave extract; q-NMR; antioxidant properties; HPLC-UV/PAD MS analysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Amri, B.; Martino, E.; Vitulo, F.; Corana, F.; Kaâb, L.-B.; Rui, M.; Rossi, D.; Mori, M.; Rossi, S.; Collina, S. Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties. Molecules 2017, 22, 1851.

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