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Molecules 2017, 22(1), 108; doi:10.3390/molecules22010108

Antioxidant and Anti-Osteoporotic Activities of Aromatic Compounds and Sterols from Hericium erinaceum

Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Korea
Department of Food and Nutrition, Hannam University, Daejeon 34430, Korea
College of Pharmacy, Chungnam National University, Daejeon 34134, Korea
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 14 November 2016 / Revised: 2 January 2017 / Accepted: 2 January 2017 / Published: 11 January 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1183 KB, uploaded 11 January 2017]   |  


Hericium erinaceum, commonly called lion’s mane mushroom, is a traditional edible mushroom widely used in culinary applications and herbal medicines in East Asian countries. In this study, a new sterol, cerevisterol 6-cinnamate (6), was isolated from the fruiting bodies of H. erinaceum together with five aromatic compounds 15 and five sterols 711. The chemical structures of these compounds were elucidated using chemical and physical methods and comparison of HRESIMS, 1D-NMR (1H, 13C, and DEPT) and 2D-NMR (COSY, HMQC, HMBC, and NOESY) spectra with previously reported data. The antioxidant and anti-osteoporotic activities of extracts and the isolated compounds 111 were investigated. All compounds exhibited peroxyl radical-scavenging capacity but only compounds 1, 3, and 4 showed potent reducing capacity. Moreover, compounds 1, 2, 4, and 5 showed moderate effects on cellular antioxidant activity and inhibited the receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastic differentiation. These results suggested that H. erinaceum could be utilized in the development of natural antioxidant and anti-osteoporotic nutraceuticals and functional foods. View Full-Text
Keywords: Hericium erinaceum; hericiaceae; antioxidant; anti-osteoporosis; sterol; aromatic compound Hericium erinaceum; hericiaceae; antioxidant; anti-osteoporosis; sterol; aromatic compound

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Li, W.; Lee, S.H.; Jang, H.D.; Ma, J.Y.; Kim, Y.H. Antioxidant and Anti-Osteoporotic Activities of Aromatic Compounds and Sterols from Hericium erinaceum. Molecules 2017, 22, 108.

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