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Molecules 2016, 21(9), 1172; doi:10.3390/molecules21091172

The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease

1
Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA
2
Department of Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Robert Kiss
Received: 29 July 2016 / Revised: 26 August 2016 / Accepted: 1 September 2016 / Published: 3 September 2016
(This article belongs to the Special Issue Cardiotonic Steroids)
View Full-Text   |   Download PDF [1028 KB, uploaded 3 September 2016]   |  

Abstract

Na/K-ATPase has been extensively studied for its ion pumping function, but, in the past several decades, has been identified as a scaffolding and signaling protein. Initially it was found that cardiotonic steroids (CTS) mediate signal transduction through the Na/K-ATPase and result in the generation of reactive oxygen species (ROS), which are also capable of initiating the signal cascade. However, in recent years, this Na/K-ATPase/ROS amplification loop has demonstrated significance in oxidative stress related disease states, including obesity, atherosclerosis, heart failure, uremic cardiomyopathy, and hypertension. The discovery of this novel oxidative stress signaling pathway, holds significant therapeutic potential for the aforementioned conditions and others that are rooted in ROS. View Full-Text
Keywords: Na/K-ATPase; oxidative stress; pNaKtide; obesity; cardiovascular disease Na/K-ATPase; oxidative stress; pNaKtide; obesity; cardiovascular disease
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Srikanthan, K.; Shapiro, J.I.; Sodhi, K. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease. Molecules 2016, 21, 1172.

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