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Molecules 2016, 21(9), 1126; doi:10.3390/molecules21091126

Aspirination of α-Aminoalcohol (Sarpogrelate M1)

Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon-si, Gyeonggi-do 420-743, Korea
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 3 August 2016 / Revised: 23 August 2016 / Accepted: 24 August 2016 / Published: 25 August 2016
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [1128 KB, uploaded 25 August 2016]   |  

Abstract

Aspirination of α-aminoalcohol (sarpogrelate M1) has been performed under various general esterification conditions. In most cases, the desired aspirinate ester was obtained at a low yield with unexpected byproducts, the formation of which was mostly derived from the chemical properties of the tertiary α-amino group. After systematic analysis of those methods, the aspirinated sarpogrelate M1 was prepared using a two-step approach combining salicylate ester formation and acetylation. View Full-Text
Keywords: aspirin; sarpogrelate; α-aminoalcohol; esterification aspirin; sarpogrelate; α-aminoalcohol; esterification
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Park, S.; Lee, J.; Shin, K.J.; Seo, J.H. Aspirination of α-Aminoalcohol (Sarpogrelate M1). Molecules 2016, 21, 1126.

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