Next Article in Journal
Insecticidal Properties of a Highly Potent Wax Isolated from Dolichandra cynanchoides Cham
Previous Article in Journal
Polyamine Metabolites Profiling for Characterization of Lung and Liver Cancer Using an LC-Tandem MS Method with Multiple Statistical Data Mining Strategies: Discovering Potential Cancer Biomarkers in Human Plasma and Urine
Article Menu
Issue 8 (August) cover image

Export Article

Correction published on 24 October 2016, see Molecules 2016, 21(10), 1413.

Open AccessArticle
Molecules 2016, 21(8), 1049; doi:10.3390/molecules21081049

Anti-Inflammatory Effects of 6,8-Diprenyl-7,4′-dihydroxyflavanone from Sophora tonkinensis on Lipopolysaccharide-Stimulated RAW 264.7 Cells

1
College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang-si, Gyeonggi-do 410-820, Korea
2
New Drug Preclinical & Analytical Team, Life Science R & D Center, SK Chemicals, 310 Pangyo-ro 463-400, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 13 May 2016 / Revised: 5 August 2016 / Accepted: 8 August 2016 / Published: 11 August 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2539 KB, uploaded 25 October 2016]   |  

Abstract

The anti-inflammatory effects and molecular mechanism of 6,8-diprenyl-7,4′-dihydroxyflavanone (DDF), one of the flavanones found in Sophora tonkinensis, were assessed in vitro through macrophage-mediated inflammation in the present study. The anti-inflammatory effects of DDF were not previously reported. DDF inhibited the production of nitric oxide and the expression of tumor necrosis factor α, interleukin-1β, and interleukin-6. Furthermore, the activation of nuclear factor-κB (NF-κB) and extracellular signal-regulated kinases (ERKs) in lipopolysaccharide-stimulated macrophages was suppressed by treatment with DDF. Therefore, DDF demonstrated potentially anti-inflammatory effects via the blockade of NF-κB and ERK activation in macrophages. View Full-Text
Keywords: 6,8-diprenyl-7,4′-dihydroxyflavanone; anti-inflammatory; nuclear factor-κB; extracellular signal-regulated kinases 6,8-diprenyl-7,4′-dihydroxyflavanone; anti-inflammatory; nuclear factor-κB; extracellular signal-regulated kinases
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chae, H.-S.; Yoo, H.; Kim, Y.-M.; Choi, Y.H.; Lee, C.H.; Chin, Y.-W. Anti-Inflammatory Effects of 6,8-Diprenyl-7,4′-dihydroxyflavanone from Sophora tonkinensis on Lipopolysaccharide-Stimulated RAW 264.7 Cells. Molecules 2016, 21, 1049.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top