Next Article in Journal
Special Issue: “Functional Dendrimers”
Previous Article in Journal
Synthesis and Structure-Activity Relationship of Some New Thiophene-Based Heterocycles as Potential Antimicrobial Agents
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(8), 1041; doi:10.3390/molecules21081041

Synthesis and Characterization of Process-Related Impurities of Antidiabetic Drug Linagliptin

Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai 201203, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Received: 22 June 2016 / Revised: 3 August 2016 / Accepted: 5 August 2016 / Published: 9 August 2016
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1927 KB, uploaded 10 August 2016]   |  

Abstract

Linagliptin, a xanthine derivative, is a highly potent, selective, long-acting and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes. During the process development of linagliptin, five new process-related impurities were detected by high performance liquid chromatography (HPLC). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, HRMS, 1H-NMR, 13C-NMR and IR) as described in this article. The identification of these impurities should be useful for quality control and the validation of the analytical method in the manufacture of linagliptin. View Full-Text
Keywords: linagliptin; type 2 diabetes; impurities; synthesis; characterization linagliptin; type 2 diabetes; impurities; synthesis; characterization
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Huang, Y.; He, X.; Wu, T.; Zhang, F. Synthesis and Characterization of Process-Related Impurities of Antidiabetic Drug Linagliptin. Molecules 2016, 21, 1041.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top