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Molecules 2016, 21(8), 1006; doi:10.3390/molecules21081006

Microfluidic Devices in Advanced Caenorhabditis elegans Research

1
Institute of Molecular and Cellular Biology, Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
2
Department of Engineering Design, Indian Institute of Technology Madras, Chennai 600 036, India
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 31 May 2016 / Revised: 19 July 2016 / Accepted: 27 July 2016 / Published: 2 August 2016
(This article belongs to the Special Issue Micro/Nano Fluidics and Bio-MEMS)
View Full-Text   |   Download PDF [4272 KB, uploaded 2 August 2016]   |  

Abstract

The study of model organisms is very important in view of their potential for application to human therapeutic uses. One such model organism is the nematode worm, Caenorhabditis elegans. As a nematode, C. elegans have ~65% similarity with human disease genes and, therefore, studies on C. elegans can be translated to human, as well as, C. elegans can be used in the study of different types of parasitic worms that infect other living organisms. In the past decade, many efforts have been undertaken to establish interdisciplinary research collaborations between biologists, physicists and engineers in order to develop microfluidic devices to study the biology of C. elegans. Microfluidic devices with the power to manipulate and detect bio-samples, regents or biomolecules in micro-scale environments can well fulfill the requirement to handle worms under proper laboratory conditions, thereby significantly increasing research productivity and knowledge. The recent development of different kinds of microfluidic devices with ultra-high throughput platforms has enabled researchers to carry out worm population studies. Microfluidic devices primarily comprises of chambers, channels and valves, wherein worms can be cultured, immobilized, imaged, etc. Microfluidic devices have been adapted to study various worm behaviors, including that deepen our understanding of neuromuscular connectivity and functions. This review will provide a clear account of the vital involvement of microfluidic devices in worm biology. View Full-Text
Keywords: worm chips; microfluidics devices; C. elegans; worm immobilization; model organism; nematode worm worm chips; microfluidics devices; C. elegans; worm immobilization; model organism; nematode worm
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Muthaiyan Shanmugam, M.; Subhra Santra, T. Microfluidic Devices in Advanced Caenorhabditis elegans Research. Molecules 2016, 21, 1006.

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