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Molecules 2016, 21(7), 878; doi:10.3390/molecules21070878

Radical Smiles Rearrangement: An Update

Institut de Chimie Moléculaire de Reims, UMR CNRS 7312, Université de Reims-Champagne-Ardenne, Faculté de Pharmacie, 51 rue Cognacq-Jay, F-51096 Reims Cedex, France
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Academic Editor: Fawaz Aldabbagh
Received: 12 May 2016 / Revised: 28 June 2016 / Accepted: 28 June 2016 / Published: 6 July 2016
(This article belongs to the Special Issue Free Radicals in Organic Synthesis)
View Full-Text   |   Download PDF [3245 KB, uploaded 6 July 2016]   |  

Abstract

Over the decades the Smiles rearrangement and its variants have become essential synthetic tools in modern synthetic organic chemistry. In this mini-review we summarized some very recent results of the radical version of these rearrangements. The selected examples illustrate the synthetic power of this approach, especially if it is incorporated into a domino process, for the preparation of polyfunctionalized complex molecules. View Full-Text
Keywords: radical chemistry; Smiles rearrangement; domino reactions; radical cascade; heterocycle radical chemistry; Smiles rearrangement; domino reactions; radical cascade; heterocycle
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Allart-Simon, I.; Gérard, S.; Sapi, J. Radical Smiles Rearrangement: An Update. Molecules 2016, 21, 878.

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