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Molecules 2016, 21(3), 359; doi:10.3390/molecules21030359

New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China
These authors contributed equally to this works.
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 20 January 2016 / Revised: 29 February 2016 / Accepted: 9 March 2016 / Published: 17 March 2016
(This article belongs to the Collection Herbal Medicine Research)
View Full-Text   |   Download PDF [2240 KB, uploaded 17 March 2016]   |  

Abstract

Autophagy is a universal catabolic cellular process for quality control of cytoplasm and maintenance of cellular homeostasis upon nutrient deprivation and environmental stimulus. It involves the lysosomal degradation of cellular components such as misfolded proteins or damaged organelles. Defects in autophagy are implicated in the pathogenesis of diseases including cancers, myopathy, neurodegenerations, infections and cardiovascular diseases. In the recent decade, traditional drugs with new clinical applications are not only commonly found in Western medicines, but also highlighted in Chinese herbal medicines (CHM). For instance, pharmacological studies have revealed that active components or fractions from Chaihu (Radix bupleuri), Hu Zhang (Rhizoma polygoni cuspidati), Donglingcao (Rabdosia rubesens), Hou po (Cortex magnoliae officinalis) and Chuan xiong (Rhizoma chuanxiong) modulate cancers, neurodegeneration and cardiovascular disease via autophagy. These findings shed light on the potential new applications and formulation of CHM decoctions via regulation of autophagy. This article reviews the roles of autophagy in the pharmacological actions of CHM and discusses their new potential clinical applications in various human diseases. View Full-Text
Keywords: autophagy; natural products; novel functions; Chinese herbal medicines autophagy; natural products; novel functions; Chinese herbal medicines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Law, B.Y.K.; Mok, S.W.F.; Wu, A.G.; Lam, C.W.K.; Yu, M.X.Y.; Wong, V.K.W. New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy. Molecules 2016, 21, 359.

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