Next Article in Journal
Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao
Previous Article in Journal
Azidation in the Difunctionalization of Olefins
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(3), 349; doi:10.3390/molecules21030349

A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans

1
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China
2
School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China
3
Laboratory of China-Korea Molecular Pharmacognosy, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 23 January 2016 / Revised: 4 March 2016 / Accepted: 8 March 2016 / Published: 16 March 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [340 KB, uploaded 16 March 2016]   |  

Abstract

A new indole alkaloid named bufobutarginine (1), along with three known bufotenines, namely, serotonin (2), bufotenidine (3), and bufotenine (4), were isolated from the water extract of toad venom. Their structures were elucidated by spectral methods. This is the first time that arginine has been found to be involved in the biosynthesis of bufotenines in parotid of toad. The cytotoxic activities of these compounds have been assayed against A375 and A549 cell lines by the MTT method; however, they showed no cytotoxic activities. View Full-Text
Keywords: Bufo bufo gargarizans ; toad venom; bufobutarginine; cytotoxic activity Bufo bufo gargarizans ; toad venom; bufobutarginine; cytotoxic activity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Dai, Y.-H.; Shen, B.; Xia, M.-Y.; Wang, A.-D.; Chen, Y.-L.; Liu, D.-C.; Wang, D. A New Indole Alkaloid from the Toad Venom of Bufo bufo gargarizans. Molecules 2016, 21, 349.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top