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Molecules 2016, 21(3), 354; doi:10.3390/molecules21030354

Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao

1,†
,
2,†
,
2
,
1
,
1
,
1
,
1,2,* and 1,2,*
1
Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China
2
Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 5 February 2016 / Revised: 3 March 2016 / Accepted: 10 March 2016 / Published: 16 March 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1521 KB, uploaded 16 March 2016]   |  

Abstract

Four new aromatic constituents, astraflavonoids A (1), B (2), C (3), and astramemoside A (4), along with sixteen known ones 5–20 were obtained from the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. Their structures were elucidated by chemical and spectroscopic methods. Among the known isolates, 14 was obtained from the Astragalus genus for the first time, while 7–12, 18–20 were isolated from the species for the first time. The effects of the compounds obtained from the plant on glucose consumption were analyzed in differentiated L6 myotubes in vitro, whereby compounds 1, 2, 3, 7, 8, 10, 11, 14, 15 and 18 displayed significant promoting effects on glucose consumption in L6 myotubes. Among them, the activities of 1, 2 and 7 were comparable to that of insulin, which suggested that these compounds may be involved in glucose metabolism and transport. View Full-Text
Keywords: Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao.; stem; structure elucidation; aromatic constituents; L6 cells; glucose consumption Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao.; stem; structure elucidation; aromatic constituents; L6 cells; glucose consumption
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MDPI and ACS Style

Hao, J.; Li, J.; Li, X.; Liu, Y.; Ruan, J.; Dong, Y.; Zhang, Y.; Wang, T. Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao. Molecules 2016, 21, 354.

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