Synthesis of New Functionalized Indoles Based on Ethyl Indol-2-carboxylate
AbstractSuccessful alkylations of the nitrogen of ethyl indol-2-carboxylate were carried out using aq. KOH in acetone. The respective N-alkylated acids could be obtained without separating the N-alkylated esters by increasing the amount of KOH and water. The use of NaOMe in methanol led to transesterification instead of the alkylation, while the use of NaOEt led to low yields of the N-alkylated acids. Hydrazinolysis of the ester gave indol-2-carbohydrazide which then was allowed to react with different aromatic aldehydes and ketones in ethanol catalyzed by acetic acid. Indol-2-thiosemicarbazide was used in a heterocyclization reaction to form thiazoles. The new structures were confirmed using NMR, mass spectrometry and X-ray single crystal analysis. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Boraei, A.T.A.; El Ashry, E.S.H.; Barakat, A.; Ghabbour, H.A. Synthesis of New Functionalized Indoles Based on Ethyl Indol-2-carboxylate. Molecules 2016, 21, 333.
Boraei ATA, El Ashry ESH, Barakat A, Ghabbour HA. Synthesis of New Functionalized Indoles Based on Ethyl Indol-2-carboxylate. Molecules. 2016; 21(3):333.Chicago/Turabian Style
Boraei, Ahmed T.A.; El Ashry, El S.H.; Barakat, Assem; Ghabbour, Hazem A. 2016. "Synthesis of New Functionalized Indoles Based on Ethyl Indol-2-carboxylate." Molecules 21, no. 3: 333.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.