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Molecules 2016, 21(3), 276; doi:10.3390/molecules21030276

Synthesis and Bioactivities of Novel Pyrazole Oxime Derivatives Containing a 5-Trifluoromethylpyridyl Moiety

1
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China
2
Nantong Fengtian Chemical Industry Co. Ltd., Nantong 226005, China
3
School of Chemical and Biological Engineering, Nantong Vocational University, Nantong 226007, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 1 February 2016 / Revised: 19 February 2016 / Accepted: 23 February 2016 / Published: 27 February 2016
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [596 KB, uploaded 27 February 2016]   |  

Abstract

In this study, in order to find novel biologically active pyrazole oxime compounds, a series of pyrazole oxime derivatives containing a 5-trifluoromethylpyridyl moiety were synthesized. Preliminary bioassays indicated that most title compounds were found to display good to excellent acaricidal activity against Tetranychus cinnabarinus at a concentration of 200 μg/mL, and some designed compounds still showed excellent acaricidal activity against Tetranychus cinnabarinus at the concentration of 10 μg/mL, especially since the inhibition rates of compounds 8e, 8f, 8l, 8m, 8n, 8p, and 8q were all 100.00%. Interestingly, some target compounds exhibited moderate to good insecticidal activities against Plutella xylostella and Aphis craccivora at a concentration of 200 μg/mL; furthermore, compounds 8e and 8l possessed outstanding insecticidal activities against Plutella xylostella under the concentration of 50 μg/mL. View Full-Text
Keywords: pyrazole oxime; 5-trifluoromethylpyridyl; synthesis; bioactivity pyrazole oxime; 5-trifluoromethylpyridyl; synthesis; bioactivity
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Dai, H.; Chen, J.; Li, H.; Dai, B.; He, H.; Fang, Y.; Shi, Y. Synthesis and Bioactivities of Novel Pyrazole Oxime Derivatives Containing a 5-Trifluoromethylpyridyl Moiety. Molecules 2016, 21, 276.

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